Results 91 to 100 of about 1,403,331 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Factors Influencing Economic Integration in East Asia During 1980-2012 Considering the Role of Japan [PDF]

open access: yesFaslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2015
The spread of high economic growth among East Asian countries in the last three decades resulted in increasing attention regarding these countries’ development models.
Nahid Pour-Rostami
doaj  

The Impact of Foreign Direct Investment in Japan: Case Studies of the Automobile, Finance, and Health Care Industries [PDF]

open access: yes
Having historically received very little foreign direct investment, Japan has experienced a substantial increase in such inflows in recent years. This paper analyzes the impact of the growing presence of foreign firms on the Japanese economy through ...
Ralph Paprzycki
core  

The effects of processing instruction and re-exposure on interpretation discourse level tasks: the case of Japanese passive forms [PDF]

open access: yes, 2010
The present study was conducted to investigate possible interpretation discourse level effects of processing instruction and re-exposure to processing instruction on the acquisition of a specific feature of the Japanese linguistics system: namely ...
Hikima, Noriko
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Studies in the Anglo-Japanese Alliance (1902-1923) [PDF]

open access: yes
Daniels examined British media views of Japan by sampling local and national dailies, with emphasis on The Times and The Economist and magazines like Punch, The Graphic and The Illustrated London News.
David Steeds   +3 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Executive Compensation in Japan: Estimating Levels and Determinants from Tax Records [PDF]

open access: yes
Most studies of executive compensation have data on pay but not total income. Because exchange-listed Japanese firms (unlike exchange-listed U.S. firms) need not disclose executive compensation figures in their securities filings, most studies on Japan ...
Eric Rasmusen   +2 more
core  

PERUBAHAN STRUKTUR AKTIF KE PASIF KALIMAT BAHASA JEPANG [PDF]

open access: yes, 2015
Puspa, Ika AnggraeniWijaya. 2014. “PerubahanStrukturAktifkePasifKalimatBahasaJepang”. Thesis, Departement of Japanese Studies Faculty of Humanities. Diponegoro University. The First Advisor Dra. Sri PujiAstuti, M. Pd. Second Advisor Lina Rosliana , S.S.,
Ika , Anggraeni
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

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