Results 131 to 140 of about 1,403,331 (309)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

A review of the Japanese longline fishery for tunas and billfishes in the eastern Pacific Ocean, 1993-1997 [PDF]

open access: yes, 2003
English: This report reviews the Japanese longline fishery in the eastern Pacific Ocean during the 1993-1997 period, extending the studies for the 1956-1992 period made by other investigators.
Bayliff, William H., Okamoto, Hiroaki
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Schizophrenia genetics in the genome-wide era: a review of Japanese studies. [PDF]

open access: yesNPJ Schizophr, 2017
Kanazawa T   +3 more
europepmc   +1 more source

Japanese Mass Communication Studies

open access: yesJapanese Sociological Review, 1987
Japanese mass communication studies were started to be influenced by the American mass communication studies after the second world war. I. Shimizu published “Social Psychology” (1951). The book was very influential to the early studies of mass communication. He argued the tremendous impact of mass communication on the modern society. That work was the
openaire   +2 more sources

Market Share and Exchange Rate Pass-through:Competition among Exporters of the Same Nationality [PDF]

open access: yes
Using a sample from January 1988 to December 2005 for exports of five Japanese major ports to six destination countries, we examine the effect of market share (with respect to competitors from the same country) on exchange rate pass-through (henceforth ...
Yushi Yoshida
core  

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin   +2 more
wiley   +1 more source

Expansion Abroad and Jobs at Home - Evidence from Japanese Multinational Enterprises [PDF]

open access: yes
This paper examines the exporting job hypothesis that expansion of overseas operations of manufacturing multinational enterprises (MNEs) reduces home employment using data for Japanese MNEs.
Kyoji Fukao, Nobuaki Yamashita
core   +1 more source

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