Results 201 to 210 of about 85,801 (308)

Is a Clinical Trial With a Non‐Bioequivalent Batch Necessary? The Critical Role of Intrasubject Variability in Olaparib Formulation Bridging by PBPK

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 203-213, July 2026.
Although physiologically based pharmacokinetic (PBPK) modeling is increasingly being used to support oral drug formulation bridging, the acceptance by regulatory agencies is low. One of the primary concerns is the absence of clinical pharmacokinetic (PK) data from a non‐bioequivalent (non‐BE) batch during model validation.
Jin Dong, Andrea Moir, Xavier Pepin, Elizabeth Lowe, Sandy Hopkins, Weifeng Tang, Diansong Zhou   +6 more
wiley   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Coca-Cola^® dissolution therapy for a bezoar impacted in the second portion of the duodenum: a case report. [PDF]

Int J Surg Case Rep
Ishii Y, Shingo M, Matsui Y, Sasaki A.
europepmc   +1 more source

Jejunum

, 2013
Jeremy Jones, Tariq Walizai, Daniel Bell
openaire   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

AL Amyloidosis Presenting With Chronic Gastrointestinal Symptoms in a Patient With Lymphoplasmacytic Lymphoma. [PDF]

ACG Case Rep J
Fansa S, Ahmed A, Osman M, Kawas H, Robertson S, Mohiuddin S.   +5 more
europepmc   +1 more source

Volvulus nodosus of the small intestine: Differences in foals and adults

Equine Veterinary Education, Volume 38, Issue 7, Page e440-e445, July 2026.
Summary Background Volvulus nodosus is a strangulating lesion of the small intestine described only in foals and in just one case in older horses. Huskamp et al. (1982, 1998) described the pathophysiology of volvulus nodosus in foals, but to date, there is no description of the pathophysiology of volvulus nodosus in adults.
M. Gandini, G. Giusto
wiley   +1 more source

Integrated analyses of host genetics and gut microbiota provide mechanistic insights into feed efficiency in ducks. [PDF]

J Anim Sci Biotechnol
Zhao H, Yang X, Dong X, Fei J, Li P, Kinkpe L, Wang S, Wei J, Zhou W, Hou S, Zhang Y, Wang X.   +11 more
europepmc   +1 more source

MALIGNANT LEIOMYOMA OF JEJUNUM

Annals of Surgery, 1953
A R K, MATTHEWS, E H, QUANDT
openaire   +3 more sources

Risk factors for strangulating lipoma obstruction and lipomata in horses

Equine Veterinary Journal, Volume 58, Issue 4, Page 1005-1015, July 2026.
Abstract Background Strangulating lipoma obstruction (SLO) is the most common cause of equine small intestinal strangulation and is fatal without surgery. Currently, epidemiological information is primarily limited to signalment‐related risk factors and requires further investigation.
Alex Gillen, Diana Hassel, Sam W. Gonzalez, Victoria Savage, Margaret Mudge, Andrew Wood, Hattie Barnes, Anje Bauck, David Freeman, Katarzyna Dembek, Liara M. Gonzalez, Debra C. Archer   +11 more
wiley   +1 more source