Results 51 to 60 of about 1,748,427 (276)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Anthropos Today: reflections on modern equipment and A machine to make a future: biotech chronicles
RECIIS, 2009 Princeton University Press, New Jersey; 2003 ISBN 978-0691115665 Princeton University Press, New Jersey; 2006 ISBN 978 ...
Messias Basques
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
PLoS ONE, 2019 Jersey and Kashmiri cattle are important dairy breeds that contribute significantly to the total milk production of the Indian northern state of Jammu and Kashmir.
Shakil Ahmad Bhat +7 more
doaj +1 more source
An Anomalous Case of Southern Sympathy: New Jersey\u27s Civil War Stance
, 2017 A popular narrative of the Civil War assumes that all Northern states stood united behind President Abraham Lincoln in their loyalty to the Union. However, the case of New Jersey suggests that this narrative of devotion is simply a myth.
Hawk, Emily A
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
COMPARACIÓN BIOECONÓMICA DE GRUPOS RACIALES HOLSTEIN, JERSEY Y HOLSTEIN×JERSEY EN COSTA RICA
Agronomía Mesoamericana, 2012 El objetivo del presente estudio fue determinar el rendimiento bioeconómico de las razas puras Holstein y Jersey con el cruce F1 Holstein×Jersey. Se comparó el rendimiento bioeconómico de estos grupos raciales en la zona Bosque Muy Húmedo Premontano de ...
Bernardo Vargas-Leit\u00F3n +2 more
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source