Results 21 to 30 of about 115,543 (68)

The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review

Molecular Neurobiology, 2018
One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication between the gut and the brain.
M. Sochocka, K. Donskow-Łysoniewska, B. Diniz, D. Kurpas, E. Brzozowska, J. Leszek   +5 more
semanticscholar   +1 more source

Physico-geographical mesoregions of Poland: Verification and adjustment of boundaries on the basis of contemporary spatial data

, 2018
Jerzy Solon1 • Jan Borzyszkowski2 • Małgorzata Bidłasik2 • Andrzej Richling34 • Krzysztof Badora5 • Jarosław Balon6 • Teresa Brzezińska-Wójcik7 • Łukasz Chabudziński7 • Radosław Dobrowolski7 • Izabela Grzegorczyk2 • Miłosz Jodłowski6 • Mariusz Kistowski8
J. Solon, J. Borzyszkowski, M. Bidłasik, A. Richling, K. Badora, Jarosław Balon, T. Brzezińska-Wójcik, Łukasz Chabudziński, R. Dobrowolski, I. Grzegorczyk, M. Jodłowski, M. Kistowski, R. Kot, Paweł Krąż, J. Lechnio, A. Macias, A. Majchrowska, E. Malinowska, P. Migoń, U. Myga-Piątek, J. Nita, E. Papińska, J. Rodzik, Małgorzata Strzyż, S. Terpiłowski, W. Ziaja   +25 more
semanticscholar   +1 more source

Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach

Diabetes, 2013
Metabolomic discovery of biomarkers of type 2 diabetes (T2D) risk may reveal etiological pathways and help to identify individuals at risk for disease.
Anna Floegel, N. Stefan, Zhonghao Yu, K. Mühlenbruch, D. Drogan, H. Joost, A. Fritsche, H. Häring, M. Hrabě de Angelis, A. Peters, M. Roden, C. Prehn, R. Wang-Sattler, T. Illig, M. Schulze, J. Adamski, H. Boeing, T. Pischon   +17 more
semanticscholar   +1 more source

Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source

New England Journal of Medicine, 2019
Background Cryptogenic strokes constitute 20 to 30% of ischemic strokes, and most cryptogenic strokes are considered to be embolic and of undetermined source.
H. Diener, R. Sacco, D. Easton, C. Granger, R. Bernstein, S. Uchiyama, J. Kreuzer, Lisa Cronin, Daniel Cotton, Claudia Grauer, M. Brueckmann, M. Chernyatina, G. Donnan, J. Ferro, M. Grond, B. Kallmünzer, J. Krupiński, Byung‐Chul Lee, R. Lemmens, J. Masjuán, M. Odinak, J. Saver, P. Schellinger, D. Toni, K. Toyoda   +24 more
semanticscholar   +1 more source

Hierarchy of demographic and social determinants of mental health: analysis of cross-sectional survey data from the Global Mind Project

BMJ Open
Objectives To understand the extent to which various demographic and social determinants predict mental health status and their relative hierarchy of predictive power in order to prioritise and develop population-based preventative approaches.
Jerzy Bala, J. Newson, Tara C. Thiagarajan   +2 more
semanticscholar   +1 more source

Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial.

JAMA psychiatry, 2019
Importance Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established.
E. Daly, M. Trivedi, A. Janik, Honglan Li, Yun Zhang, Xiang Li, R. Lane, P. Lim, A. Duca, D. Hough, M. Thase, J. Zajecka, A. Winokur, I. Divacka, A. Fagiolini, W. Cubała, I. Bitter, P. Blier, R. Shelton, P. Molero, H. Manji, W. Drevets, Jaskaran Singh   +22 more
semanticscholar   +1 more source

The EuroHeart Failure survey programme-- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis.

European Heart Journal, 2003
BACKGROUND The European Society of Cardiology (ESC) has published guidelines for the investigation of patients with suspected heart failure and, if the diagnosis is proven, their subsequent management.
J. Cleland, K. Swedberg, F. Follath, M. Komajda, A. Cohen-Solal, J. C. Aguilar, R. Dietz, A. Gavazzi, R. Hobbs, J. Korewicki, H. Madeira, V. Moiseyev, I. Préda, W. Gilst, J. Widimský, N. Freemantle, J. Eastaugh, J. Mason   +17 more
semanticscholar   +1 more source

Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae

Nature, 2005
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human ...
J. Galagan, S. Calvo, Christina A. Cuomo, Li‐Jun Ma, J. Wortman, S. Batzoglou, Su-In Lee, M. Baştürkmen, Christina C. Spevak, J. Clutterbuck, V. Kapitonov, J. Jurka, C. Scazzocchio, M. Farman, Jonathan Butler, S. Purcell, S. Harris, G. Braus, O. Draht, S. Busch, C. d’Enfert, C. Bouchier, G. Goldman, D. Bell-Pedersen, S. Griffiths-Jones, J. Doonan, Jae-Hyuk Yu, Kay Vienken, A. Pain, M. Freitag, E. Selker, D. Archer, M. Peñalva, B. Oakley, M. Momany, Toshihiro Tanaka, Toshitaka Kumagai, K. Asai, M. Machida, W. Nierman, D. Denning, M. Caddick, M. Hynes, M. Paoletti, R. Fischer, B. Miller, P. Dyer, M. Sachs, S. Osmani, B. Birren   +49 more
semanticscholar   +1 more source

The HLA genomic loci map: expression, interaction, diversity and disease

Journal of Human Genetics, 2009
The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal position 6p21 that encodes the six classical transplantation HLA genes and at least 132 protein coding genes that have important roles in the regulation of the immune ...
T. Shiina, K. Hosomichi, H. Inoko, Jerzy K. Kulski   +3 more
semanticscholar   +1 more source

Human metabolic individuality in biomedical and pharmaceutical research

Nature, 2011
Genome-wide association studies (GWAS) have identified many risk loci for complex diseases, but effect sizes are typically small and information on the underlying biological processes is often lacking.
K. Suhre, So-Youn Shin, A. Petersen, R. Mohney, D. Meredith, Brigitte Wägele, E. Altmaier, P. Deloukas, J. Erdmann, E. Grundberg, C. Hammond, M. H. de Angelis, G. Kastenmüller, A. Köttgen, F. Kronenberg, M. Mangino, C. Meisinger, T. Meitinger, H. Mewes, M. Milburn, C. Prehn, Johannes Raffler, J. Ried, W. Römisch-Margl, N. Samani, K. Small, H. Wichmann, G. Zhai, T. Illig, T. Spector, J. Adamski, N. Soranzo, C. Gieger   +32 more
semanticscholar   +1 more source