Results 171 to 180 of about 130,208 (268)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Differential Cranial Nerve Susceptibility to Compression by a Giant Cerebellopontine Angle Epidermoid Cyst: A Case Report and Literature Review. [PDF]

Cureus
Díaz Lagunas JO, Becerril-Mejía A, Revuelta R, Aco Cruz G, Flores-Velasco H, Bahena-Quinto MDC, Beristain Y, Herrera-Mejía EM.   +7 more
europepmc   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Preoperative urodynamics and the risk of overdiagnosis and overtreatment of occult urinary incontinence in continent women with advanced pelvic organ prolapse. [PDF]

World J Urol
Hwang SM, de Toledo LGM, da Silva Carramão S, de Jesus CRM, de Carvalho SZ, Auge APF.   +5 more
europepmc   +1 more source

Data‐Driven Modeling of Composition–Processing–Microstructure Relations for Recycled Aluminum Cast Alloys

Advanced Science, EarlyView.
Interpretable machine learning reveals how composition and processing govern the formation and microstructural burden of Fe‐rich intermetallic compounds in recycled Al–Si–Fe–Mn alloys. By separating morphology selection from morphology‐conditioned burden partitioning, this framework shows that identical Fe contents can yield different intermetallic ...
Jaemin Wang, Waleed Mohammed, Dierk Raabe   +2 more
wiley   +1 more source

Correction: Clinically significant prostate cancer detection with deep learning in a multi-center magnetic resonance imaging study. [PDF]

Sci Rep
Alzate-Grisales JA, Mora-Rubio A, Perán-Teruel M, Beltrán AN, Torres CR, García JMO, García-García F, Tabares-Soto R, García-Gómez JM, de la Iglesia-Vayá M.   +9 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

A New Customizable Surfactant LLPS Strategy for Sustainable and Highly Efficient Radioactive Metal Ion Separation

Advanced Science, EarlyView.
A diluent‐free, customizable liquid–liquid phase separation (LLPS) platform enables highly efficient radioactive metal ion extraction and stripping. By encapsulating hydrophobic extractants into an ionic surfactant‐rich condensed phase, this LLPS system leverages synergistic electrostatic and coordination interactions.
Ruihan Yan, Yifu Hu, Wentao Wang, Zhi Cao, Meiwen Cao, Weifang Zheng, Guoan Ye, Taihong Yan   +7 more
wiley   +1 more source

Extensive Cutaneous and Scalp Metastases From Hormone Receptor-Positive Breast Cancer Successfully Treated With CDK4/6 Inhibitor Therapy: A Case Report. [PDF]

Cureus
Fernández-Ferreira R, Bautista-Piña V, Barragán-Dessavre M, Cruz-Morales G, Montaño-Hernández J, Salas-Pérez A, Vicuña-González RM, Anaya-Jiménez R, Moreno-López R, García-López SM, Loya-Aguilar IA.   +10 more
europepmc   +1 more source