Results 71 to 80 of about 53,012 (265)

Genetic and Pathological Testing Attitudes for Parkinson's Disease in At‐Risk Relatives

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is increasingly recognized as a neurodegenerative disorder with a broad clinical spectrum and diverse biomarkers enabling early detection. α‐synuclein seed amplification assays (SAA) and genetic testing now allow identification of PD pathology in asymptomatic individuals.
Tal Weil, Anat Mirelman, Roy N. Alcalay, Nurit Omer, Penina Ponger, Avner Thaler   +5 more
wiley   +1 more source

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Movement Disorders, EarlyView.
Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang, Riley H. Grant, Dan Vitale, Carlos F. Hernandez, Samantha Hong, Hampton L. Leonard, Mary B. Makarious, Lara M. Lange, Matthew Solomonson, Peter Heutink, Allison A. Dilliott, Kamalini Ghosh Galvelis, Mike A. Nalls, Andrew B. Singleton, Cornelis Blauwendraat, the Global Parkinson's Genetics Program (GP2)   +15 more
wiley   +1 more source

The GBA1 p.E427K (p.E388K) Variant Is a Risk Factor for Synucleinopathies: A Meta‐Analysis

Movement Disorders, EarlyView.
Abstract Background Variants in GBA1 are important genetic risk factors for synucleinopathies, including Parkinson's disease (PD). Although several GBA1 variants are established risk or severity modifiers, the role of the p.E427K variant remains unclear.
Leah V. Chifamba, Sitki Cem Parlar, Emma N. Somerville, Lang Liu, Eric Yu, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Jennifer A. Ruskey, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Irina Miliukhina, Lior Greenbaum, Sharon Hassin‐Baer, Orly Goldstein, Mandy Radefeldt, Peter Bauer, Christian Beetz, Allison A. Dilliott, James C. Beck, Konstantin Senkevich, ROPAD Study Group, The Parkinson's Foundation PD GENEration Study, Christine Klein, Roy N. Alcalay, Ziv Gan‐Or   +30 more
wiley   +1 more source

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source

Following Similar Paths: What American Jews and Muslims Can Learn From One Another

American Journal of Islam and Society
As the dust settled on the 2024 U.S. presidential election, a few demographic trends came into focus. Perhaps one important trend saw that the war in Gaza was an incredibly divisive issue for Democrats.
Benjamin Sax
doaj   +1 more source

Why Active Representation Varies: Cultural Stereotypes and Differential Treatment by Street‐Level Bureaucrats

Public Administration and Development, EarlyView.
ABSTRACT How do cultural stereotypes influence the likelihood that minority street‐level bureaucrats (SLBs) will actively represent marginalized subgroups within their ethnocultural community? While existing scholarship on representative bureaucracy has focused on the conditions under which minority SLBs engage in active representation, this study ...
Sohad Amaria, Einat Lavee, Nissim Cohen
wiley   +1 more source

Enabling Variant Proteogenomic Assay Development Through a Peptide Target Selection Pipeline and Web Application

PROTEOMICS, EarlyView.
ABSTRACT The quantification of key protein variants can guide precision oncology to enable better identification of driver mutations. Bottom‐up assays infer parent protein levels through the quantification of surrogate peptides. Assay methods designed for absolute quantification of protein variants, such as multiple reaction monitoring mass ...
Constantinos Blidjios, Pallab Bhowmick, Vincent R. Richard, Yassene Mohammed, Christoph H. Borchers   +4 more
wiley   +1 more source

(In)justice in Smart Cities: Barriers and an Integrative Framework for Solution Pathways From a Global Perspective

Sustainable Development, EarlyView.
ABSTRACT Smart city initiatives aim for sustainability and inclusiveness, but recent evidence shows that they often lead to injustices. Although this contradiction has received growing academic attention, a comprehensive understanding of how justice is addressed within smart city practices remains limited.
Md. Nazmul Haque, Emilio Costales, Dominik Beckers, Ayyoob Sharifi, Samar Aad, Luca Mora   +5 more
wiley   +1 more source

Operationalizing the Metaverse for Urban Sustainability: Evidence From an Expert Panel and the Seoul Metaverse City Case Study

Sustainable Development, EarlyView.
ABSTRACT Smart cities and urban digital twins have fostered the emergence of immersive environments, such as the metaverse. While contemporary scholarlship has increasingly examined the integration of the metaverse within smart city infrastructures, the critical nexus between urban sustainability and the metaverse remains largely under‐researched. This
Jose Manuel Diaz‐Sarachaga, Ayyoob Sharifi   +1 more
wiley   +1 more source

From armed roots to airline routes in South America: A dual imprinting perspective

Strategic Management Journal, EarlyView.
Abstract Reserch Summary We propose that founding partner relationships can leave distinct imprints on organizations that differ in durability and in how they respond to subsequent changes involving the founding partner. Examining South American airlines founded between 1919 and 1984, we argue and find that such relationships simultaneously create an ...
Kunyuan Qiao, Shon R. Hiatt, Wesley D. Sine   +2 more
wiley   +1 more source