Results 71 to 80 of about 52,903 (88)

Abstract 2112: Chimeric antigen receptor macrophages (CAR-M) sensitize solid tumors to anti-PD1 immunotherapy

Cancer Research, 2022
Despite the remarkable efficacy achieved by CAR-T cell therapy in hematologic malignancies, achieving efficacy against solid tumors has been challenging.
S. Pierini, R. Gabbasov, Alison Worth, Ilyssa Ramos, Daniel Blumenthal, Y. Ohtani, L. Gabitova, Michael Ball, S. Abramson, T. Condamine, M. Klichinsky   +10 more
semanticscholar   +1 more source

The spatial structure and dynamical state of the open cluster NGC 2112

, 2021
This paper investigates the spatial structure and dynamical state of the old open cluster NGC 2112 based on likely cluster members from Gaia Early Data Release 3. Using the Density-Based Spatial Clustering of Applications with Noise (DBSCAN) algorithm,
Xinhua Gao, S. Xu, Lei Xue
semanticscholar   +1 more source

The extended halo and tidal tails of the old open cluster NGC 2112

Nippon Tenmon Gakkai obun kenkyu hokoku
This paper investigates the spatial structure and tidal tails of the nearby ($\sim$1100 pc) old open cluster NGC 2112 ($\sim$1.2 Gyr) based on reliable cluster members from Gaia-DR3.
Xinhua Gao, Chengyu Zhu
semanticscholar   +1 more source

Abstract 2112: Identification of biomarkers associated with sensitivity to a novel PCNA inhibitor (AOH1996) by CRISPRi screening

Cancer Research
Proliferating cell nuclear antigen (PCNA) plays an essential role in regulating DNA synthesis and repair and is essential for cancer cell growth and survival.
Long Gu, Ming li, Chun-Wei Chen, Robert J. Hickey, L. Malkas   +4 more
semanticscholar   +1 more source

Abstract 2112: Association between visceral fat obesity and perioperative complications of undernutrition in laparoscopic surgery for colorectal cancer

Cancer Research
Visceral obesity and malnutrition are each associated with poor prognosis in gastrointestinal cancers. This study investigates the impact of undernutrition combined with visceral obesity on perioperative complications in laparoscopic colorectal ...
Kengo Haruna, N. Miyoshi, S. Fujino, Rie Mizumoto, Rie Hayashi, Mitsunobu Takeda, Y. Sekido, Tsuyoshi Hata, Atsushi Hamabe, T. Ogino, Mamoru Uemura, Hirofumi Yamamoto, Y. Doki, H. Eguchi   +13 more
semanticscholar   +1 more source

Abstract LB-187: Hsp90 inhibitor SNX-2112 enhances neoantigen presentation on the surface of tumor cells

Immunology, 2019
Introduction: SNX-5422 is the orally active prodrug of SNX-2112, a potent, highly selective inhibitor of heat-shock protein 90 (Hsp90) with promising anti-tumor activity in clinical trials. SNX-5422 enhanced anti-PD-1 activity in MC38 murine model.
Megan C Yap, J. Walker, K. Baker, R. Fahlman, E. Orlemans, P. LaPointe   +5 more
semanticscholar   +1 more source

Abstract B026: SNX-2112 interferes with mitochondrial metabolism in TP53 mutant tumors

, 2018
Introduction: SNX-5422 is an orally active prodrug of SNX-2112, a potent, highly selective inhibitor of Hsp90 with epigenetic character that has shown antitumor activity in clinical trials. K562 cells have loss of p53 expression by nonsense-mediated mRNA
E. Orlemans
semanticscholar   +1 more source

Abstract 3842: Potent antitumor activity of the HSP90 inhibitor SNX-2112 in type 1 papillary renal cell carcinoma

Experimental and Molecular Therapeutics, 2018
Papillary renal-cell carcinoma (pRCC) is the second most common form of kidney cancer, accounting for 15 to 20% of all cases. There are currently no treatment options of proven benefit for patients with advanced pRCC. The type 1 subset of pRCC tumors are
R. Pahwa, Abhigya Giri, C. Sourbier, Craig J. Thomas, W. Linehan, L. Neckers, R. Srinivasan   +6 more
semanticscholar   +1 more source

Abstract 2112: FoxO3a activation by HDAC class IIa inhibition induces cell cycle arrest in pancreatic cancer cells

, 2017
Pancreatic cancer is highly chemo-resistant associated with oncogenic mutations such as KRAS and/or p53. The effect of conventional chemotherapy is not sufficient and new target and strategy is urgently needed.
M. Usami, S. Kikuchi, K. Takada, Yusuke Sugama, Y. Arihara, Naotaka Hayasaka, Hajime Nakamura, Yuki Ikeda, Y. Kamihara, M. Hirakawa, Makoto Yoshida, M. Kobune, K. Miyanishi, J. Kato   +13 more
semanticscholar   +1 more source

Abstract 2112: ABCC11/MRP8 and ABCB1/MDR1 confer eribulin resistance to breast cancer cells

, 2016
Background: Eribulin is a key drug for the patients with metastatic breast cancer; however, the mechanisms of how breast cancer cells become resistant to eribulin have not been fully elucidated.
Takaaki Oba, Ken-ichi Ito, S. Taniguchi
semanticscholar   +1 more source