Results 51 to 60 of about 1,998,863 (253)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Job Creation, Job Destruction and Firms’ International Trade Involvement [PDF]

SSRN Electronic Journal, 2008
One of the most important predictions made in recent international trade literature based on heterogeneous firms concerns the within-industry job reallocation from firms not involved in international markets to those that are. This paper quantifies the extent of this reallocation using a dataset of Belgian manufacturing firms from 1998 to 2004 ...
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Relationship between Leader-Member Exchange and Job Involvement from Nurses' Perspective [PDF]

Egyptian Journal of Health Care
Background: Leader-member exchange is the quality of the exchange relationship between the supervisor and the nurses of an agency. This relation had a positive effect on staff nurses' job involvement and organizational achievement. Purpose: Determine the
Eman Said, Hayam Ahmed El Shrief
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Having a Calling on Board: Effects of Calling on Job Satisfaction and Job Performance Among South Korean Newcomers

Frontiers in Psychology, 2019
Despite increasing research on calling, how calling functions for those experiencing transition from school to work and how their calling prior to working relates to later well-being and job outcomes has been understudied.
Jiyoung Park, Sinae Kim, Myoungki Lim, Young Woo Sohn   +3 more
doaj   +1 more source

The correlation of employees involvement (EI) and turnover [PDF]

, 2001
Plan BThe purpose of this research project is to study the relationship between applying employee involvement and the retention of employees. The interest is driven primarily from the view that employee involvement (EI) has a positive effect on ...
Vera, Ricardo J.
core  

Job-shop scheduling with an adaptive neural network and local search hybrid approach [PDF]

, 2006
This article is posted here with permission from IEEE - Copyright @ 2006 IEEEJob-shop scheduling is one of the most difficult production scheduling problems in industry.
Yang, S, Shengxiang Yang, Yang, Shengxiang, Shengxiang Yang (7582940)   +3 more
core   +1 more source