Results 51 to 60 of about 1,414,367 (299)

An effective hybrid algorithm for multi-objective flexible job-shop scheduling problem

Advances in Mechanical Engineering, 2018
Genetic algorithm is one of primary algorithms extensively used to address the multi-objective flexible job-shop scheduling problem. However, genetic algorithm converges at a relatively slow speed.
Xiabao Huang, Zailin Guan, Lixi Yang
doaj   +1 more source

Developing Multistage Heuristic Algorithm To Minimize Idle Time And Makespan In Job Shop Scheduling [PDF]

Engineering and Technology Journal, 2010
The behavior and performance of job shops have been the focus andattention in both operations research and operations management literature. Job shop scheduling has received this large amount of attention, because it has the potential to dramatically ...
Mahmoud Abbas Mahmoud
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Scheduling practice and recent developments in flow shop and job shop scheduling

, 2009
Each plant and/or service provider performs several tasks to satisfy customer demand. Every task consumes several resources in order to be completed. Scheduling deals with the allocation of limited resources to tasks over time. Because the resources used
Yenisey, Mehmet Mutlu
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Flexible job-shop scheduling problem with parallel batch machines based on an enhanced multi-population genetic algorithm

Complex & Intelligent Systems
The flexible job-shop scheduling problem (FJSP) with parallel batch processing machine (PBM) is one of those long-standing issues that needs cutting-edge approaches. It is a recent extension of standard flexible job shop scheduling problems.
Lirui Xue, Shinan Zhao, Amin Mahmoudi, Mohammad Reza Feylizadeh   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

REAL-TIME SCHEDULING IN A SENSORISED FACTORY USING CLOUD-BASED SIMULATION WITH MOBILE DEVICE ACCESS

South African Journal of Industrial Engineering, 2017
Scheduling is a challenge that persists in the operational phase of the manufacturing life-cycle. The challenge can be attributed to the complex, dynamic, and stochastic nature of a manufacturing system.
Stephan Snyman, James Bekker
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source