Results 81 to 90 of about 199,857 (394)

Developing Multistage Heuristic Algorithm To Minimize Idle Time And Makespan In Job Shop Scheduling [PDF]

Engineering and Technology Journal, 2010
The behavior and performance of job shops have been the focus andattention in both operations research and operations management literature. Job shop scheduling has received this large amount of attention, because it has the potential to dramatically ...
Mahmoud Abbas Mahmoud
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Real-Time Selection System of Dispatching Rules for the Job Shop Scheduling Problem

Machines, 2023
Personalized market demands make the job shop scheduling problem (JSSP) increasingly complex, and the need for scheduling methods that can solve scheduling strategies quickly and easily has become very urgent.
Anran Zhao, Peng Liu, Yunfeng Li, Zheyu Xie, Longhao Hu, Haoyuan Li   +5 more
doaj   +1 more source

Particle swarm optimization applied to job shop scheduling [PDF]

, 2007
In this project we have to apply the particle swarm optimization algorithm to job shop scheduling problem. Job shop scheduling is a combinatorial optimization problem where we have to arrange the jobs which may or may not be processed in every machine in
Dwivedi , Piyush, Vishal , Vivek
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Scheduling of non-repetitive lean manufacturing systems under uncertainty using intelligent agent simulation [PDF]

, 2008
World-class manufacturing paradigms emerge from specific types of manufacturing systems with which they remain associated until they are obsolete. Since its introduction the lean paradigm is almost exclusively implemented in repetitive manufacturing ...
Mousavi, A, Papadopoulou, T C
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

REAL-TIME SCHEDULING IN A SENSORISED FACTORY USING CLOUD-BASED SIMULATION WITH MOBILE DEVICE ACCESS

South African Journal of Industrial Engineering, 2017
Scheduling is a challenge that persists in the operational phase of the manufacturing life-cycle. The challenge can be attributed to the complex, dynamic, and stochastic nature of a manufacturing system.
Stephan Snyman, James Bekker
doaj   +1 more source