Results 11 to 20 of about 51,609 (225)
Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation. [PDF]
Angew Chem Int Ed EnglProteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Schäfer D +11 more
europepmc +2 more sources
Targeted decrease of portal hepatic pressure gradient improves ascites control after TIPS
Hepatology, EarlyView., 2022 The river diagram demonstrates that after transjugular intrahepatic portosystemic shunt insertion (TIPS) the majority of patients without ascites and 50% of the patients with ascites detectable at ultrasound, show the best response in the long term follow‐up.
Alexander Queck +14 more
wiley +1 more source
Missglückte Begegnung – Der kurze Briefwechsel zwischen Leopold von Buch und Goethe
HiN - Alexander von Humboldt im Netz. Internationale Zeitschrift für Humboldt-Studien, 2018 Zusammenfassung Die Bekanntschaft zwischen Leopold von Buch und Johann Wolfgang von Goethe war von Missverständnissen und Skepsis dem jeweils anderen gegenüber geprägt.
Thomas Schmuck
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Energy Conservation in the Acetogenic Bacterium Clostridium aceticum
Microorganisms, 2021 In times of global warming caused by the extensive use of fossil fuels, the need to capture gaseous carbon compounds is growing bigger. Several groups of microorganisms can fix the greenhouse gas CO2.
Anja Wiechmann, Volker Müller
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História, Ciências, Saúde: Manguinhos, 2006 Este artigo apresenta a obra científica do poeta alemão Johann Wolfgang von Goethe (1749-1832), a qual engloba os campos da anatomia humana e animal, ótica, geologia, mineralogia, química, botânica, morfologia e meteorologia.
Izabela Maria Furtado Kestler
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Cahiers du MIMMOC, 2021 From historical figure to Goethean legend, Götz von Berlichingen was a fictional hero, for himself, for Germanic culture and for the young and passionate Johann Wolfgang von Goethe.
Géraldine Ponsolle
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Wortfolge, 2017 Johann Wolfgang von Goethe: Baśń. Das Märchen. Wydanie polskie i niemieckie. Przekł. Krystyna Krzemień-Ojak, wstęp Wojciech Kunicki, pod red. Jarosława Ławskiego. Białystok: Wydawnictwo Alter Studio, 2015: 154 s.
Renata Dampc-Jarosz
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The at-issue status of ideophones in German: An experimental approach
Glossa, 2022 Formal linguistics generally assumes that form-meaning relations in spoken language are arbitrary and not iconic. Ideophones, such as the English splish-splash have been considered exceptions to this rule of arbitrariness.
Cornelia Ebert +3 more
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Hanno Beck: Ein Ehrenbürger der Erde. A. von Humboldt und seine Bedeutung
HiN - Alexander von Humboldt im Netz. Internationale Zeitschrift für Humboldt-Studien, 2023 Kein Abstract vorhanden.
Ingo Schwarz, Hanno Beck
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Beilstein Journal of Organic Chemistry, 2008 A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully 13C/15N-labelled tripeptide 1 could be isolated in a typical batch ...
Sven T. Breitung +5 more
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