Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham +9 more
wiley +1 more source
Academy, a battleground for justice: a call for prioritarian scholarship. [PDF]
Shrime MG.
europepmc +1 more source
Unravelling charge transport mechanisms in graphene nanosheet networks: by combining temperature‐dependent conductivity measurements with a Random Resistor Network model, this study identifies a transition from hopping‐dominated conduction to a band‐like transport mechanism.
Alessandro Grillo +9 more
wiley +1 more source
Trends in acute care of cerebrovascular events- a joinpoint analysis with German hospital data from 2000 to 2021. [PDF]
Schmidt R +4 more
europepmc +1 more source
Fractional Skyrmion Tubes in Chiral‐Interfaced 3D Magnetic Nanowires
In chiral 3D helical magnetic nanowires, the coupling between the geometric and magnetic chirality provides a way to create topological spin states like vortex tubes. Here, it is demonstrated how the breaking of this coupling in interfaced 3D nanowires of opposite chirality leads to even more complex topological spin states, such as fractional ...
John Fullerton +11 more
wiley +1 more source
Docking domains from modular polyketide synthases and their use in engineering. [PDF]
Collin S, Weissman KJ.
europepmc +1 more source
Joining of simian virus 40 DNA molecules at endonuclease R Eco RI sites by polynucleotide ligase and analysis of the products by agarose gel electrophoresis [PDF]
F. A. J. de Vries +2 more
openalex +1 more source
Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer +10 more
wiley +1 more source
A multi-user multi-robot multi-goal multi-device human-robot interaction manipulation benchmark. [PDF]
Yoshida A +5 more
europepmc +1 more source

