Results 121 to 130 of about 794,230 (296)
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
ANALYSIS OF THE CONSTRUCTION OF THE CAR TRAILER FRAME IN TERMS OF CHANGING THE ASSEMBLY TECHNOLOGY
Scientific Journal of Silesian University of Technology. Series TransportCar trailers are quite a popular means of transport and are offered in many versions, from single axle light trailers with a maximum permissible weight of 750 kg, through two- or more-axle specialized trailers.
Jacek CABAN +4 more
doaj +1 more source
Неофилология, 2017 The questions connected with joining of the Turkmen earths to the Russian empire are considered, namely those armed events which occurred in 1879 and 1881 under command of Russian generals on the one hand and leaders of a Turkmen home guard on the other ...
Muradgeldi Soyegov
doaj
Dissimilar Resistance Welding of NiTi Microwires for High-Performance SMA Bundle Actuators
ActuatorsShape memory alloys (SMAs) are becoming a more important factor in actuation technology. Due to their unique features, they have the potential to save weight and installation space as well as reduce energy consumption.
Dominik Scholtes +4 more
doaj +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source