Results 51 to 60 of about 41,215 (215)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Selective Wander Join: Fast Progressive Visualizations for Data Joins
Informatics, 2019 Progressive visualization offers a great deal of promise for big data visualization; however, current progressive visualization systems do not allow for continuous interaction.
Marianne Procopio +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Assessment of the hardness of S890QL material welded joins [PDF]
Journal of Research and Innovation for Sustainable SocietyThe need to reduce the mass of products manufactured by welding processes has led to the replacement of the basic steel materials, such as construction steels, by steels with high mechanical properties, such as hard and brittle steels.
Adrian Florea +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Edge Degree Weight of Sequential Join of Graphs
Science Journal of University of Zakho, 2013 Let the weight w of an edge e= uv={u,v} of a graph G be defined by w(e)=deg(u)+deg(v)-2 and the weight of G be defined by w(G)= ∑ e ∈ E(G)w(e), where E(G) is the edge set of G.
Khidir R. Sharaf, Didar A. Ali
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Another Fanconi anemia gene joins the club
The Journal of Clinical InvestigationFanconi anemia (FA) is the most common inherited bone marrow failure disorder, caused by pathogenic variants in genes involved in the FA DNA repair pathway.
Claire C. Homan +2 more
doaj +1 more source
A technique for n-way joins in wireless sensor networks [PDF]
Database Systems Journal, 2016 The join queries are operations that require more energy for their execution. In wireless sensor networks, energy is a determinant factor for the network survival.
Djail BOUBEKEUR +2 more
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