Results 41 to 50 of about 327,730 (260)
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Frontiers in Psychology, 2017 In contrast to individual tasks, a specific social setting is created when two partners work together on a task. How does such a social setting affect memory for task-related information?
Ullrich Wagner +3 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Role-Specific Brain Activations in Leaders and Followers During Joint Action
Frontiers in Human Neuroscience, 2018 Much of social interaction in human life requires that individuals perform different roles during joint actions, the most basic distinction being that between a leader and a follower.
Léa A. S. Chauvigné, Steven Brown
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Collective Emotions and Joint Action
Journal of Social Ontology, 2016 In contemporary philosophy of collective intentionality, emotions, feelings, moods, and sentiments do not figure prominently in debates on the explanation and justification of joint action.
Mikko Salmela, Michiru Nagatsu
doaj +2 more sources
eJournal de la Recherche sur l'Intervention en Éducation Physique et Sport, 2014 In the school system in Geneva (Switzerland), physical education (PE) teachers and teachers alternately teach physical education at the primary school. PE teachers are given responsibility by cantonal laws to act as "methodologists" for teachers.
Adrián Cordoba, Benoît Lenzen
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source