Results 61 to 70 of about 2,439,370 (299)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Development of Primary School Teacher’s Competences in the Process of Solving Professional Tasks
Психологическая наука и образование (2007. Online), 2017 This article deals with the problem of development of primary school teacher’s professional competences in the sphere of organization and formation elementary school pupils’ skills of educational cooperation. The article provides results of the research,
Sanina S.P.,
doaj +1 more source
Hypovitaminosis D in recent onset rheumatoid arthritis is predictive of reduced response to treatment and increased disease activity: a 12 month follow-up study. [PDF]
, 2015 BACKGROUND: Vitamin D displays immunomodulatory activities and has been proposed as a potential player in the pathogenesis of rheumatoid arthritis (RA).
Barchetta, Ilaria +7 more
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Психологическая наука и образование, 2019 The paper presents outcomes of a study on the features of social and communicative competence in joint activities in children aged 7—8 years with developmental delays.In our study, the children displayed reduced ability to negotiate, to distribute ...
Egorova M.A., , Zarechnaya A.A.**
doaj +1 more source
Femoroacetabular Impingement (FAI) Syndrome : the medical imaging perspective [PDF]
, 2014 Introduction: Sports persons, physicians, orthopods and radiologists have become increasingly aware of the extra stress that is imposed on the hip joints with excessive activity particularly when superadded weight bearing and asymmetrical variations from
Zammit, Anthony
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
An investigation into the tourism and hospitality scholarly activity currently being undertaken in Irish higher education institutions [PDF]
, 2008 The purpose of this article is to describe the tourism and hospitality scholarly activity currently taking place in Irish higher education (HE) institutions. A number of approaches to tourism and hospitality research are identified in the literature.
Baum, T.G., O'Connor, N.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source