Results 71 to 80 of about 2,439,370 (299)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
ПРОВЕДЕНИЕ АУДИТА ОПЕРАЦИЙ СОВМЕСТНОЙ ДЕЯТЕЛЬНОСТИ С ИСПОЛЬЗОВАНИЕМ МЕЖДУНАРОДНОГО ОПЫТА
Фінансово-кредитна діяльність: проблеми теорії та практики, 2014 Рассмотрено экономическое содержание и направления аудиторской проверки совместной деятельности на основе отечественного законодательства и международного опыта.
H. H. Батищева +1 more
doaj
The C Terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit [PDF]
, 1999 Ku is a heterodimeric protein with double-stranded DNA end-binding activity that operates in the process of nonhomologous end joining. Ku is thought to target the DNA-dependent protein kinase (DNA-PK) complex to the DNA and, when DNA bound, can interact ...
Jeggo, P A +4 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Suivre à la trace l’activité de deux co-acteurs
Activités, 2008 Our research aims at observing a joint and mediated writing situation. In the activity we studied, two users were asked to co-write a procedural text with the help of a numerical artefact, composed of three types of resources: a video showing the content
Magali Beldame
doaj +1 more source
Adopting a Grounded Theory Approach to Cultural-Historical Research: Conflicting Methodologies or Complementary Methods? [PDF]
, 2008 Grounded theory has long been regarded as a valuable way to conduct social and educational research. However, recent constructivist and postmodern insights are challenging long-standing assumptions, most notably by suggesting that grounded theory can be ...
Seaman, Jayson O.
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Social interaction, languaging and the operational conditions for the emergence of observing
Frontiers in Psychology, 2014 In order to adequately understand the foundations of human social interaction, we need to provide an explanation of our specific mode of living based on linguistic activity and the cultural practices with which it is interwoven.
Vincenzo eRaimondi
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source