Results 41 to 50 of about 1,992,408 (295)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Laxity, Balance, and Alignment of a Simulated Kinematic Alignment Total Knee Arthroplasty
Arthroplasty Today, 2023 Background: Kinematic alignment (KA) and related personalized alignment strategies in total knee arthroplasty (TKA) target restoration of native joint line obliquity and alignment.
Adam I. Edelstein, MD +3 more
doaj +1 more source
Joint Alignment and Modeling of Correlated Behavior Streams [PDF]
2013 IEEE International Conference on Computer Vision Workshops, 2013 The Variable Time-Shift Hidden Markov Model (VTS-HMM) is proposed for learning and modeling pairs of correlated streams. Unlike previous coupled models for time series, the VTS-HMM accounts for varying time shifts between correlated events in pairs of streams having different properties. The VTS-HMM is learned on a set of pairs of unaligned streams and,
Liliana Lo Presti +2 more
openaire +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Journal of Orthopaedic Surgery and Research, 2019 Background Recently, there has been increasing interest in mobile-bearing total knee arthroplasty (TKA). However, changes in biomechanics with respect to femoral component alignment in mobile-bearing TKA have not been explored in depth.
Yong-Gon Koh +5 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2019 Background Gait kinematics after total hip replacement only partly explain the differences in the joint moments in the frontal plane between hip osteoarthritis patients after hip replacement and healthy controls.
Stefan van Drongelen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
HMM word-to-phrase alignment with dependency constraints [PDF]
, 2010 In this paper, we extend the HMMwordto-phrase alignment model with syntactic dependency constraints. The syntactic dependencies between multiple words in one language are introduced into the model in a bid to produce coherent alignments.
Way, Andy, Ma, Yanjun
core +3 more sources
3D Printed Titanium Wedges for Distraction Arthrodesis of the Subtalar Joint
Foot & Ankle Orthopaedics, 2023 Category: Hindfoot Introduction/Purpose: Distraction arthrodesis of the subtalar joint is performed to restore height and correct deformity in the case of subtalar joint arthrosis, malalignment of the rear foot, calcaneal fracture, or other pathologies ...
Christopher D. Kreulen MD, MS +1 more
doaj +1 more source