Results 61 to 70 of about 1,744,464 (376)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Inflammatory Pseudotumor Complicated by Recurrent Dislocations after Revision Total Hip Arthroplasty

Case Reports in Orthopedics, 2014
A 71-year-old female with a history of right total hip arthroplasty presented with an enlarging pseudotumor. Pseudotumor is a known complication following metal-on-metal and metal-on-conventional polyethylene and metal-on-highly cross-linked polyethylene
John Ryan Quinn, Jason Lee, Ran Schwarzkopf   +2 more
doaj   +1 more source

Free Vibration of a Taut Cable with Two Discrete Inertial Mass Dampers

Applied Sciences, 2019
Recently, inertial mass dampers (IMDs) have shown superior control performance over traditional viscous dampers (VDs) in vibration control of stay cables.
Zhihao Wang, Fangfang Yue, Hui Gao
doaj   +1 more source

Herramienta de toma de decisiones para la implementación nacional del sistema multilateral de acceso y distribución de beneficios del Tratado Internacional sobre los Recursos Fitogenéticos [PDF]

, 2018
This decision making tool is designed to assist national policy makers and other stakeholders to identify appropriate measures to implement the Plant Treaty’s multilateral system of access and benefit-sharing in their countries.
Joint Capacity Building Programme
core  

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

Impact of β-Carotene Enrichment on Carotenoid Composition and Gene Expression in Artemia Metanauplii

Metabolites
Background: Carotenoids play essential nutritional and physiological roles in aquatic animals. Since aquatic species cannot synthesize carotenoids de novo, they must obtain these compounds from their diet to meet the physiological and adaptive ...
Weilong Wang, Zhuojun Ma, Weiquan Li, Yucai Xue, Amina S. Moss, Meiqin Wu   +5 more
doaj   +1 more source

STUDY ON ENERGY EXCHANGE PROCESSES IN NORMAL OPERATION OF METRO ROLLING STOCK WITH REGENERATIVE BRAKING SYSTEMS

Nauka ta progres transportu, 2017
Purpose. The analysis of the existing studies showed that the increasing of energy efficiency of metro rolling stock becomes especially important and requires timely solutions.
A. O. Sulym, S. O. Muzhychuk, P. O. Khozya, O. O. Melnyk, V. V. Fedorov   +4 more
doaj   +1 more source

Outil décisionnel pour la mise en oeuvre nationale du système multilatéral d’accès et de partage des avantages aux termes du Traité international sur les ressources phytogénétiques pour l’alimentation et l’agriculture [PDF]

, 2018
This decision making tool is designed to assist national policy makers and other stakeholders to identify appropriate measures to implement the Plant Treaty’s multilateral system of access and benefit-sharing in their countries.
Joint Capacity Building Programme
core  

Metal-organic framework based on hinged cube tessellation as transformable mechanical metamaterial [PDF]

, 2019
Mechanical metamaterials exhibit unusual properties, such as negative Poisson???s ratio, which are difficult to achieve in conventional materials. Rational design of mechanical metamaterials at the microscale is becoming popular partly because of the ...
Choe, Wonyoung, Jang, Woo-Dong, Jin, Eunji, Kim, Dongwook, Lah, Myoung Soo, Lee, Hosoowi, Lee, In Seong, Min, Seung Kyu   +7 more
core   +1 more source

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

FEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla, Faiza Abbas, Luigia Rossi, Mauro Magnani, Sara Biagiotti   +4 more
wiley   +1 more source