Results 61 to 70 of about 1,846,995 (349)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Shear testing of steel fiber reinforced expanded-shale lightweight concrete beams with varying of shear-span to depth ratio and stirrups

open access: yesCase Studies in Construction Materials, 2021
Aiming at achieving the beneficial effects from the lightened self-weight of structures, steel fiber reinforced expanded-shale lightweight concrete (SFRELC) is promoting to be applied in structural engineering.
Changyong Li   +5 more
doaj   +1 more source

Community Health Champions in Lincolnshire Review and Scoping Exercise Report [PDF]

open access: yes, 2013
The Lincolnshire 2012 Joint Health and Well-being Strategy identified the need to ‘develop a Community Health Champion programme for Lincolnshire building on current good practice that will enable people to volunteer to offer help and support to other ...
White, J, Woodward, J
core  

Vibration response of a hybrid steel–timber building element with uncertain material and joint parameters [PDF]

open access: hybrid, 2023
Bettina Chocholaty   +4 more
openalex   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

High-Durability Concrete with Supplementary Cementitious Admixtures Used in Corrosive Environments

open access: yesCrystals, 2021
Durability of concrete is of great significance to prolong the service life of concrete structures in corrosive environments. Aiming at the economical and environment-friendly production of concrete by comprehensive utilization of the supplementary ...
Shiming Liu   +6 more
doaj   +1 more source

Multilevel Behavioral Synchronization in a Joint Tower-Building Task [PDF]

open access: yesIEEE Transactions on Cognitive and Developmental Systems, 2017
Human to human sensorimotor interaction can only be fully understood by modeling the patterns of bodily synchronization and reconstructing the underlying mechanisms of optimal cooperation. We designed a tower-building task to address such a goal. We recorded upper body kinematics of dyads and focused on the velocity profiles of the head and wrist.
Coco, M. I.   +7 more
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

NON-PLANAR BEAM-WALL JOINTS IN TALL BUILDING STRUCTURES. [PDF]

open access: yesICE Proceedings, Structures and Buildings, 2000
Stress concentration and local deformation occur at both coplanar and non-planar beam–wall joints. However, over the years, only coplanar joints have been studied in detail. Very few studies on non-planar joints have been carried out and most designers still treat non-planar joints as hinges and neglect the possible coupling effect of beams connected ...
Kwan, AKH, Chan, WT
openaire   +3 more sources

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