Possible mechanism of static progressive stretching combined with extracorporeal shock wave therapy in reducing knee joint contracture in rats based on MAPK/ERK pathway [PDF]
Biomolecules & Biomedicine, 2023 The study aimed to observe the therapeutic effect of static progressive stretching (SPS) combined with extracorporeal shock wave therapy (ESWT) on extension knee joint contracture in rats and the effect on the mitogen-activated protein kinase (MAPK ...
Run Zhang +4 more
doaj +2 more sources
The Dose-Response Effect of the Mast Cell Stabilizer Ketotifen Fumarate on Posttraumatic Joint Contracture [PDF]
JBJS Open Access, 2021 Background:. Posttraumatic joint contracture is a debilitating complication following an acute fracture or intra-articular injury that can lead to loss of motion and an inability to complete activities of daily living.
Prism S. Schneider, MD, PhD, FRCSC +5 more
doaj +2 more sources
Pleiotropic Long-Term Effects of Atorvastatin on Posttraumatic Joint Contracture in a Rat Model [PDF]
Pharmaceutics, 2022 The antifibrotic effect of atorvastatin has already been demonstrated in several organ systems. In the present study, a rat model was used to investigate the effect of atorvastatin on posttraumatic joint contracture.
Erik Wegner +10 more
doaj +2 more sources
Role of hypoxia-mediated pyroptosis in the development of extending knee joint contracture in rats [PDF]
European Journal of Medical ResearchJoint contracture is one of the common diseases clinically, and joint capsule fibrosis is considered to be one of the most important pathological changes of joint contracture.
Quan-Bing Zhang +6 more
doaj +2 more sources
Multidisciplinary rehabilitation intervention on mobility and hemodynamics of joint contracture animal model [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background Joint contracture causes a decrease in range of motion (ROM), which severely affects activities of daily living of patients. We have investigated the effectiveness of a multidisciplinary rehabilitation on joint contracture by rat model ...
Palida Maimaiti +6 more
doaj +2 more sources
The role of leukotriene inhibition using a 5‐lipoxygenase (5‐LO) inhibitor in a joint contracture model [PDF]
Journal of Experimental Orthopaedics, 2023 Purpose Arthrofibrosis is a common inflammatory complication of joint trauma and surgery. 5lipoxygenase (5‐LO) is a key enzyme involved in inflammation.
Alexander D. Jeffs +6 more
doaj +2 more sources
The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review [PDF]
Chinese Journal of Traumatology, 2019 The clinical treatment of joint contracture due to immobilization remains difficult. The pathological changes of muscle tissue caused by immobilization-induced joint contracture include disuse skeletal muscle atrophy and skeletal muscle tissue fibrosis ...
Feng Wang +6 more
doaj +2 more sources
Overexpression of chaperonin containing T-complex polypeptide subunit zeta 2 (CCT6b) suppresses the functions of active fibroblasts in a rat model of joint contracture [PDF]
Journal of Orthopaedic Surgery and Research, 2019 Background Joint contracture is a fibrous disease characterized as joint capsule fibrosis that results in joint dysfunction and disability. The purpose of this study was to analyze the biological activities of chaperonin containing T-complex polypeptide (
Xiaoyou Yi +6 more
doaj +2 more sources
Fat grafting rescues radiation-induced joint contracture. [PDF]
Stem Cells, 2020 Abstract The aim of this study was to explore the therapeutic effects of fat grafting on radiation-induced hind limb contracture. Radiation therapy (RT) is used to palliate and/or cure a range of malignancies but causes inevitable and progressive fibrosis of surrounding soft tissue.
Borrelli MR +10 more
europepmc +4 more sources
The influence of Dupuytren's disease fingers contracture degree on surgical treatment outcome [PDF]
Vojnosanitetski Pregled, 2017 Background/Aim. Dupuytren’s disease is a progressive disease of the palmar and digital fascial structures, with functional limitations. There are no clear recommendations about the optimal time of surgical repair, concerning the hand impairment.
Stepić Nenad +2 more
doaj +1 more source