Results 31 to 40 of about 830,227 (315)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Designing and implementing solution-oriented team science initiatives—a chronic pain example

Frontiers in Pain Research
Large, collaborative projects that combine researchers from multiple scientific disciplines have become an integral part of the scientific endeavor. While transdisciplinary team science projects hold great potential, they also come with a unique set of ...
Nele A. Haelterman, Armen N. Akopian, Kyle D. Allen, Yenisel Cruz-Almeida, Christopher R. Donnelly, Brendan Lee, Rebecca Lenzi, Anne-Marie Malfait, Marie Mancini, Maryann E. Martone, Joost B. Wagenaar, Kim C. Worley, the RE-JOIN Consortium   +12 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxins

Frontiers in Immunology
IntroductionPararamosis is an occupational inflammatory disease caused by contact with hairs of the caterpillar Premolis semirufa, endemic to the Brazilian Amazon and primarily affecting rubber tree workers.
Joel J. M. Gabrili, Ângela A. A. Megale, Giselle Pidde, Trent M. Woodruff, Denise V. Tambourgi   +4 more
doaj   +1 more source

The results of screw augmentation of acetabular cement spacers for the treatment of periprosthetic hip joint infection

Journal of Orthopaedic Surgery and Research, 2020
Introduction Prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) is widely used in two-stage revision arthroplasty in periprosthetic joint infection (PJI) after total hip arthroplasty (THA).
Jing-Yao Jin, Taek-Rim Yoon, Kyung-Soon Park, Sheng-Yu Jin, Dong-Min Jung, Qing-Song Li   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

PPARγ Agonism Modulates Synovial Macrophage and Cartilage Responses in an Equine Model of Synovial Inflammation—Implications for Joint Therapy

Biomolecules
Synovitis resolution is critical for joint homeostasis and prevents the progression of osteoarthritis (OA). Treatments like NSAIDs and intra-articular corticosteroids relieve symptoms by blocking pro-inflammatory mediators, but also impair the production
Slàine F. Chaimbeul, Nubia N. P. Rodrigues, Danny D. Thurston, Kirsten E. Scoggin, Jennifer Janes, Cale A. Jacobs, James N. MacLeod, Austin V. Stone, Bruno C. Menarim   +8 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Objective quantification of ligament balancing using VERASENSE in measured resection and modified gap balance total knee arthroplasty

BMC Musculoskeletal Disorders, 2018
Background Soft tissue balancing which is above all most important factor of total knee arthroplasty, has been performed by subjective methods. Recently objective orthosensor has been developed for compartment pressure measurement.
Kyu-Jin Cho, Jong-Keun Seon, Won-Young Jang, Chun-Gon Park, Eun-Kyoo Song   +4 more
doaj   +1 more source

Direct anterior approach in total hip arthroplasty: more indications and advantages than we found

Arthroplasty, 2022
Mounting attention has been oriented to the direct anterior approach (DAA) in total hip arthroplasty (THA) because of alleged advantages in terms of tissue-sparing and minimal invasiveness, as well as fast recovery after surgery in the past decades ...
Zhonghua Xu, Jun Zhang, Jie Li, Yuan Zhang   +3 more
doaj   +1 more source