Results 51 to 60 of about 1,787,266 (342)
Trehalose alleviates the phenotype of Machado–Joseph disease mouse models [PDF]
, 2020 Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration.
Cavadas, Cláudia +10 more
core +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Chikungunya Fever and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Tropical Medicine and Infectious DiseaseChikungunya fever (CHIKF) is a re-emerging infectious disease caused by the chikungunya virus (CHIKV), transmitted primarily by Aedes mosquitoes. A significant number progress to chronic chikungunya arthritis, which shares similarities with rheumatoid ...
José Kennedy Amaral +3 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2018 Background Soft tissue balancing which is above all most important factor of total knee arthroplasty, has been performed by subjective methods. Recently objective orthosensor has been developed for compartment pressure measurement.
Kyu-Jin Cho +4 more
doaj +1 more source
The use of intra-articular aneshesia as a diagnostic tool in canine lameness [PDF]
, 2012 Lameness in dogs may be difficult to localize because of mild pathologic changes or inconclusive clinical findings. Intra-articular anesthesia is proposed as a diagnostic method to localize the source of lameness.
Mosselmans, Lynn +5 more
core +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Osteoarthritis, adipokines and the translational research potential in small animal patients
Frontiers in Veterinary ScienceOsteoartritis (OA) is a debilitating disease affecting both humans and animals. In the early stages, OA is characterized by damage to the extracellular matrix (ECM) and apoptosis and depletion of chondrocytes.
Lars F. H. Theyse, Emilia M. Mazur
doaj +1 more source
Hemophilic Arthropathy: Barriers to Early Diagnosis and Management
Journal of Blood Medicine, 2022 Rubén Cuesta-Barriuso,1,2 Elena Donoso-Úbeda,3 Javier Meroño-Gallut,4 Roberto Ucero-Lozano,5 Raúl Pérez-Llanes3 1Department of Surgery and Medical-Surgical Specialties, University of Oviedo, Oviedo, Spain; 2Royal Victoria Eugenia Foundation, Madrid ...
Cuesta-Barriuso R +4 more
doaj
Patient Outcomes Following Hip and Knee Joint Replacement Surgery: Role of the Social and Physical Environment in Recovery [PDF]
, 2016 Osteoarthritis is a degenerative joint disease that affects over 27 million Americans (Centers for Disease Control & Prevention, 2014). Joint replacement surgery is often recommended for patients who do not respond to conventional medical treatment. Post-
Sampson, Brittany Anne
core +1 more source