Results 71 to 80 of about 12,189,357 (395)
Patient Outcomes Following Hip and Knee Joint Replacement Surgery: Role of the Social and Physical Environment in Recovery [PDF]
, 2016 Osteoarthritis is a degenerative joint disease that affects over 27 million Americans (Centers for Disease Control & Prevention, 2014). Joint replacement surgery is often recommended for patients who do not respond to conventional medical treatment. Post-
Sampson, Brittany Anne
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Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Journal of Blood Medicine, 2021 Richard Gooding,1 Jecko Thachil,2 Jayanthi Alamelu,3 Jayashree Motwani,4 Pratima Chowdary5 1Leicester Haemophilia Centre, Haemostasis & Thrombosis Unit, Leicester Royal Infirmary, Leicester, UK; 2Haematology Department, Manchester Royal Infirmary ...
Gooding R +4 more
doaj
FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway
Cell Communication and Signaling, 2023 Fibroblast growth factor 19 (FGF19) is recognized to play an essential role in cartilage development and physiology, and has emerged as a potential therapeutic target for skeletal metabolic diseases.
Shiyi Kan +11 more
doaj +1 more source
Spondyloarthritis: Matrix Metalloproteinasesas Biomarkers of Pathogenesis and Response to Tumor Necrosis Factor (TNF) Inhibitors [PDF]
, 2017 The term spondyloarthritis (SpA) is used to describe a group of multifactorial chronic inflammatory diseases characterized by a predisposing genetic background and clinical manifestations typically involving the sacroiliac joint.
Ada Aita +11 more
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Scientific Reports, 2023 The risk of high-temperature-related diseases is increasing owing to global warming. This study aimed to assess the trend of disease burden caused by high temperatures in Mainland China from 1990 to 2019 and to predict the trend of disease burden over ...
Jiaolong Zheng +4 more
doaj +1 more source
CANet: Cross-Disease Attention Network for Joint Diabetic Retinopathy and Diabetic Macular Edema Grading [PDF]
IEEE Transactions on Medical Imaging, 2019 Diabetic retinopathy (DR) and diabetic macular edema (DME) are the leading causes of permanent blindness in the working-age population. Automatic grading of DR and DME helps ophthalmologists design tailored treatments to patients, thus is of vital ...
X. Li +5 more
semanticscholar +1 more source
The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]
, 2019 Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M. +7 more
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