Results 281 to 290 of about 2,089,020 (348)

Genome‐Wide Aggregated Trans Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid Arthritis

open access: yesArthritis &Rheumatology, EarlyView.
Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou   +9 more
wiley   +1 more source

Gout and NLRP3 inflammasome biology

open access: yesArthritis &Rheumatology, Accepted Article.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal‐induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun   +19 more
wiley   +1 more source

The issues caused by misinformation—How workers and organizations deal with it: A systematic literature review

open access: yesJournal of the Association for Information Science and Technology, EarlyView.
Abstract In today's digital age, misinformation propagates rapidly through digital channels, blurring the lines between truth and fiction, and challenging the foundations of trust in information sources. Although affecting all spheres of life, misinformation poses a significant threat to workers highlighting a critical intersection between ...
Ashwani Malhotra   +4 more
wiley   +1 more source

Development of a continuous intensified process for conversion of hemicellulose sugars into furans using an agitated cell reactor

open access: yesBiofuels, Bioproducts and Biorefining, EarlyView.
Abstract This study addresses significant process challenges associated with the reactive nature of hemicellulose‐derived furan intermediates in aqueous mediums. A continuous agitated cell reactor was used to intensify the extractive reaction using methyl isobutyl ketone as an extractive phase to isolate in situ the furan products obtained by ...
Abdullahi Adamu   +2 more
wiley   +1 more source

Activism as education in and through the youth climate justice movement

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Young people worldwide are increasingly participating in a global movement for climate justice, yet to date, little research has examined how youth climate justice activists conceive of and experience activism as education. The present study used in‐depth, semi‐structured interviews with 16 US climate justice activists (aged 15–17) to address ...
Carlie D. Trott
wiley   +1 more source

A cross‐cultural examination of elementary students' perceptions of academic feedback

open access: yesBritish Educational Research Journal, EarlyView.
Abstract With a growing emphasis on students playing an active role in the feedback process, understanding how students perceive academic feedback is essential to support the implementation of relevant strategies that can drive better engagement. The current study explored elementary school students' perceptions of feedback in two different contexts ...
Alexandra Troy   +4 more
wiley   +1 more source

Development of Medial Subtalar Dislocation after Sports Injury: A Case Report

open access: yesHaseki Tıp Bülteni, 2011
Serdar Hakan Başaran   +2 more
doaj  

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