Results 91 to 100 of about 2,812,701 (287)

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Modeling Asymmetric Dependence Structure of Air Pollution Characteristics: A Vine Copula Approach

Mathematics
Contaminated air is unhealthy for people to breathe and live in. To maintain the sustainability of clean air, air pollution must be analyzed and controlled, especially after unhealthy events.
Mohd Sabri Ismail, Nurulkamal Masseran, Mohd Almie Alias, Sakhinah Abu Bakar   +3 more
doaj   +1 more source

Joint modeling of flood peak discharges, volume and duration: a case study of the Danube River in Bratislava

Journal of Hydrology and Hydromechanics, 2014
The study is focused on the analysis and statistical evaluation of the joint probability of the occurrence of hydrological variables such as peak discharge (Q), volume (V) and duration (t).
Bačová Mitková Veronika, Halmová Dana   +1 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Cold Chain Logistics and Joint Distribution: A Review of Fresh Logistics Modes

Systems
With the continuous development of the global logistics industry, cold chain transportation and joint distribution, as critical strategies in supply chain management, are gradually becoming key means to ensure the safe transportation of perishable goods,
Huaixia Shi, Qinglei Zhang, Jiyun Qin
doaj   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

On the Joint Distribution of Excursion Duration and Amplitude of a Narrow-Band Gaussian Process

IEEE Access, 2018
The probability density of crest amplitude and duration that exceeds a given level is used in many theoretical and practical problems in engineering that are subjected to fluctuating loads such as wind and wave loads.
Mahdi Ghane, Zhen Gao, Mogens Blanke, Torgeir Moan   +3 more
doaj   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

A modified two-stage isolated bidirectional buck-DAB converter with a full-load ZVS range

Frontiers in Energy Research
A modified two-stage buck-DAB (MBDAB) converter is proposed to improve the performance of the traditional two-stage buck-DAB (TSBDAB) converter. In the MBDAB converter, the DAB can work with fixed voltage gain and voltage-matched condition under a wide ...
Jinliang Li, Jinliang Li, Dai Wan, Dai Wan, Zhengmei Lu, Guo Xu   +5 more
doaj   +1 more source