Results 111 to 120 of about 357,990 (258)

Periprosthetic Joint Infection

BioMed Research International, 2019
Bernd Fink, Konstantinos Anagnostakos, Heinz Winkler   +2 more
openaire   +2 more sources

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review. [PDF]

Infect Dis Ther
Laffont-Lozes P, Larcher R, Artiaga A, Lavigne JP, Loubet P, Sotto A.   +5 more
europepmc   +1 more source

Oral Motion‐Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect

Advanced Science, EarlyView.
We proposed a method based on the piezoelectric effect and fabricated an implant abutment on the basis of piezoelectric ceramic. Under physiological occlusal pressure, the oral motion‐powered smart dental implant abutments interacted with water and oxygen, promoting the formation of reactive oxygen species and achieving a synergistic and highly ...
Xiyu Shi, Xiaoyu Han, Yanhui Lu, Yuan Chai, Baiyan Xiao, Shuo Liu, Boon Chin Heng, Tingting Wu, Tingjun Li, Qiaomei Ren, Ting Song, Le Chen, Dong Han, Yaru Guo, Xuliang Deng, Xuehui Zhang   +15 more
wiley   +1 more source

Accuracy and heterogeneity of histological analysis for detecting periprosthetic joint infections. [PDF]

J Orthop Surg Res
Xu J, Zhang L, Tang Y, Song Z, Chai W, Li R.   +5 more
europepmc   +1 more source

Prosthetic joint infection

Bone & Joint Research, 2019
Ahmed, S. S., Haddad, F. S.
openaire   +2 more sources

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Geographical Differences in the Epidemiology and Treatment of Candida Prosthetic Joint Infections. [PDF]

Open Forum Infect Dis
Mamona-Kilu C, Lora-Tamayo J, McNally M, Duran C, Ho R, Scarborough M, Dudareva M, Bonnet E, Escolà-Vergé L, Pardo DR, Jesuthasan G, Senneville E, Thill P, Klein S, Ronde-Oustau C, Redó MLS, Corvec S, Rossi N, Esteban J, Lemaignen A, Ribeiro TC, Mazet J, Sasso M, Costa Salles MJ, Mancheño-Losa M, Giordano G, Frank BJH, Hofstaetter JG, Allende JMB, Lortholary O, Fourcade C, Morata L, Soriano A, Dinh A, European Society of Clinical Microbiology and Infectious Diseases Study Group on Implant Associated Infections (ESGIAI) .   +34 more
europepmc   +1 more source