Results 191 to 200 of about 344,693 (260)

Enhancing the Care of Patients With Bone and Joint Infections Through Educational Interventions. [PDF]

Open Forum Infect Dis
Shah NB, Seidelman J, Belden K, Thottacherry E, Lastinger A, Nori P, Beaulieu RM, Tai DBG.   +7 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Smart Phages: Leveraging Artificial Intelligence to Tackle Prosthetic Joint Infections. [PDF]

Antibiotics (Basel)
Mehta N, Nguyen AT, Rodriguez EK, Young J.   +3 more
europepmc   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Novel Therapies for Prosthetic Joint Infections Caused by Methicillin-Resistant <i>Staphylococcus aureus</i>. [PDF]

Pathogens
Xiang X, Jin X, Yang Q, Zou L, Wang Y, Wang T, Sun X.   +6 more
europepmc   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Advances in the Application of Multimodal Nano-Antimicrobial Strategies in Prosthetic Joint Infections: A Systematic Review. [PDF]

Int J Nanomedicine
Zhang Z, Sun J, Luo Y, Huang C, Xiao W, Wang W.   +5 more
europepmc   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Rapid and Accurate Diagnosis of Joint Infections: Potential Clinical Effect of the BioFire Joint Infection Panel. [PDF]

JB JS Open Access
Jeong HS, Choi SM, Kwon YJ, Jang MO, Kim MJ, Kim S, Lee A, Kim SE, Shin SU, Kim UJ, Kang SJ, Jung SI, Shin JH, Won EJ, Kim MN, Park KH.   +15 more
europepmc   +1 more source