Results 191 to 200 of about 357,990 (258)

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Successful Management of <i>Achromobacter</i>-Associated Periprosthetic Joint Infections After Total Knee Arthroplasty: A Case Series of Ten Knees in Six Patients. [PDF]

Arthroplast Today
Singla R, Vatsya P, Malhotra V, Chauhan A, Garg G, Malhotra R.   +5 more
europepmc   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Real world use of dalbavancin for bone and joint infections: a retrospective case series in adults and children. [PDF]

BMC Res Notes
Ajapuje PS, Sameel S, Gaikwad D, Kumar PS, Dharangutti R.   +4 more
europepmc   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Bacteriophages in Hip and Knee Periprosthetic Joint Infections: A Promising Tool in the Era of Antibiotic Resistance. [PDF]

Med Sci (Basel)
Migliorini F, Schäfer L, Vaishya R, Eschweiler J, Oliva F, Driessen A, Pipino G, Maffulli N.   +7 more
europepmc   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Staphylococcus aureus fatty acid metabolism governs saeRS-mediated aggregation in joint infections. [PDF]

Nat Commun
Yu J, Li M, Wang C, Hamushan M, Hu Y, Yang Y, Jiang F, Yan J, Wang B, Chen X, Tang J, Guo G, Han P, Shen H.   +13 more
europepmc   +1 more source

Antimicrobial 3D printed implants for periprosthetic joint infections. [PDF]

Drug Deliv Transl Res
Yuste I, Luciano FC, Rodríguez C, Ramirez BI, Rapti C, Anaya BJ, Lalatsa A, Ribed-Sánchez A, Sanz-Ruiz P, González-Burgos E, Serrano DR.   +10 more
europepmc   +1 more source

Optimization of sampling protocol, specimen types, and sampling sites in periprosthetic joint infections: a retrospective study. [PDF]

J Orthop Surg Res
Chu C, Wu X, Wang Z, Zhu W, Xing Y, Zhang Z, Chen W, Sheng P.   +7 more
europepmc   +1 more source