Results 231 to 240 of about 496,797 (347)

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

open access: yesAdvanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li   +13 more
wiley   +1 more source

Mid-term results after DAIR for patients with acute periprosthetic joint infections of the hip or knee. [PDF]

open access: yesJ Orthop Surg Res
Zellner AA   +6 more
europepmc   +1 more source

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis

open access: yesAdvanced Science, EarlyView.
The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang   +5 more
wiley   +1 more source

Agreement Analysis Among Hip and Knee Periprosthetic Joint Infections Classifications. [PDF]

open access: yesDiagnostics (Basel)
Rocchi C   +6 more
europepmc   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

open access: yesAdvanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu   +17 more
wiley   +1 more source

Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis

open access: yesAdvanced Science, EarlyView.
Microneedle suction cup patches, prepared using bionic Drosophila tarsal claws, can effectively treat bacterial infectious stomatitis by rapidly and efficiently leveraging multiple effects, including antibacterial and anti‐inflammatory properties, promotion of vasodilation, and active mechanical contraction of the wound.
Jiaqi Qin   +6 more
wiley   +1 more source

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