Results 241 to 250 of about 5,299,620 (348)

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Current Concepts in Shoulder Periprosthetic Joint Infections-Are Shoulders the Same as Hips and Knees? [PDF]

J Clin Med
Frank FA, Müller AM, Morgenstern M, Kuehl R, Clauss M.   +4 more
europepmc   +1 more source

Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime–fluoroquinolone combination

, 2006
L. Legout, Éric Senneville, Richard Stern, Yazdan Yazdanpanah, C. Savage, M. Roussel-Delvalez, B. Rosele, Henri Migаud, Y Mouton   +8 more
openalex   +1 more source

Time trends in the aetiology of prosthetic joint infections: a multicentre cohort study.

Clinical Microbiology and Infection, 2016
N. Benito, N. Benito, M. Franco, A. Ribera, A. Soriano, D. Rodríguez-Pardo, L. Sorlí, G. Fresco, M. Fernández-Sampedro, M. D. Toro, L. Guío, E. Sánchez-Rivas, A. Bahamonde, M. Riera, J. Esteban, J. Baraia-Etxaburu, J. Martínez-Alvarez, A. Jover-Sáenz, Carlos J. Dueñas, A. Ramos, B. Sobrino, G. Euba, L. Morata, C. Pigrau, P. Coll, Isabel Mur, J. Ariza, F. Barcenilla, F. Pérez-Villar, L. Prats-Gispert, R. Cisterna, S. Ibarra, I. López, J. M. Santamaría, J. Cabo, David Vinuesa García, Jaime Lora-Tamayo, O. Murillo, S. Pedrero, S. Álvarez-Parrondo, R. Muedra-Font, C. Raya-Fernández, C. Rodríguez-Alonso, Antonio Vallecillo, M. A. Blanco-Martínez-de-Morentin, R. Cabo-Magadán, A. Combalía, S. García, J. Martínez-Pastor, E. Tornero, J. Merino-Pérez, J. Montejo, A. Alier, J. Horcajada, V. Plasencia, Lluís Puig, Álvaro Auñón, A. Blanco, J. García-Cañete, E. Sandoval, M. Fakkas-Fernández, C. Garces-Zarzalejo, C. Fariñas-Álvarez, M. Fariñas, L. Martínez-Martínez, Carlos A. Salas-Venero, J. Cobo, P. Ruiz-Carbajosa, M. Jordán, X. Crusi, C. Marinescu, F. Montaner, A. Ramírez, P. Corona, M. Lung, M. Muniain-Ezcurra, C. Peñas-Espinar, A. Suárez, Regino Rodríguez Álvarez, J. Cordero, M. López-Pliego, J. Palomino, A. Puente   +82 more
semanticscholar   +1 more source

Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction

Advanced Science, EarlyView.
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu, Huitong Ruan, Xiaolin Zhang, Weihan Zheng, Muhetaierjiang Mutailifu, Ling Wang, Liu Yu, Ruijun Peng, Rui Zhao, Zihan Wang, Jie Xu, Shaochuan Li, Yaobin Wu, Wenguo Cui, Mujun Lu   +14 more
wiley   +1 more source

Diagnostic work-up in periprosthetic joint infections of the knee: can the albumin-to-globulin ratio be a screening tool? [PDF]

J Orthop Traumatol
De Mauro D, Ascione T, Festa E, Marasco L, Leggieri F, Rosito S, Innocenti M, Di Pace E, Balato G.   +8 more
europepmc   +1 more source

Multi‐disciplinary antimicrobial strategies for improving orthopaedic implants to prevent prosthetic joint infections in hip and knee

Journal of Orthopaedic Research, 2016
Matthew A. Getzlaf, Eric A Lewallen, H. Kremers, Dakota L. Jones, C. Bonin, A. Dudakovic, R. Thaler, Robert C. Cohen, D. Lewallen, A. V. van Wijnen   +9 more
semanticscholar   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source

Performance evaluation of a commercial multiplex pathogen panel for the diagnosis of pediatric joint infections. [PDF]

J Clin Microbiol
Copley L, Lee G, Villani M, Tareen N, Filkins LM.   +4 more
europepmc   +1 more source