Results 251 to 260 of about 496,797 (347)

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, EarlyView.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source

Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime–fluoroquinolone combination

, 2006
L. Legout, Éric Senneville, Richard Stern, Yazdan Yazdanpanah, C. Savage, M. Roussel-Delvalez, B. Rosele, Henri Migаud, Y Mouton   +8 more
openalex   +1 more source

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1

Advanced Science, EarlyView.
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan, Yuting Zhu, Ben Tang, Yaru Xie, Mingcun Hu, Hua Su, Youhua Liu, Chun Zhang   +7 more
wiley   +1 more source

Oral tetracyclines for bone and joint infections: what do we know?

J Bone Jt Infect
Cartau T, Michon J, Verdon R, Baldolli A.   +3 more
europepmc   +1 more source

Antibiotic resistance and population structure of Staphylococcus epidermidis from prosthetic joint infections in Sweden and France. [PDF]

J Antimicrob Chemother
Edslev SM, Laurent F, Månsson E, Johannesen TB, Aarris M, Sönksen UW, Kolenda C, Söderquist B, Stegger M.   +8 more
europepmc   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

Suppressive Antibiotic Therapy in Prosthetic Joint Infections: A Contemporary Overview. [PDF]

Antibiotics (Basel)
Harrabi H, Meyer E, Dournon N, Bouchand F, Kilu CM, Perronne V, Jaffal K, d'Anglejan E, Duran C, Dinh A.   +9 more
europepmc   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Gram-Negative versus Gram-Positive Prosthetic Joint Infections [PDF]

, 2017
Bernard, Louis, Uækay, Ilker
core