Results 261 to 270 of about 5,638,528 (351)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Smart Phages: Leveraging Artificial Intelligence to Tackle Prosthetic Joint Infections. [PDF]

Antibiotics (Basel)
Mehta N, Nguyen AT, Rodriguez EK, Young J.   +3 more
europepmc   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Novel Therapies for Prosthetic Joint Infections Caused by Methicillin-Resistant <i>Staphylococcus aureus</i>. [PDF]

Pathogens
Xiang X, Jin X, Yang Q, Zou L, Wang Y, Wang T, Sun X.   +6 more
europepmc   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Advances in the Application of Multimodal Nano-Antimicrobial Strategies in Prosthetic Joint Infections: A Systematic Review. [PDF]

Int J Nanomedicine
Zhang Z, Sun J, Luo Y, Huang C, Xiao W, Wang W.   +5 more
europepmc   +1 more source

Multi‐disciplinary antimicrobial strategies for improving orthopaedic implants to prevent prosthetic joint infections in hip and knee

Journal of Orthopaedic Research, 2016
Matthew A. Getzlaf, Eric A Lewallen, H. Kremers, Dakota L. Jones, C. Bonin, A. Dudakovic, R. Thaler, Robert C. Cohen, D. Lewallen, A. V. van Wijnen   +9 more
semanticscholar   +1 more source

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source

Time trends in the aetiology of prosthetic joint infections: a multicentre cohort study.

Clinical Microbiology and Infection, 2016
N. Benito, N. Benito, M. Franco, A. Ribera, A. Soriano, D. Rodríguez-Pardo, L. Sorlí, G. Fresco, M. Fernández-Sampedro, M. D. Toro, L. Guío, E. Sánchez-Rivas, A. Bahamonde, M. Riera, J. Esteban, J. Baraia-Etxaburu, J. Martínez-Alvarez, A. Jover-Sáenz, Carlos J. Dueñas, A. Ramos, B. Sobrino, G. Euba, L. Morata, C. Pigrau, P. Coll, Isabel Mur, J. Ariza, F. Barcenilla, F. Pérez-Villar, L. Prats-Gispert, R. Cisterna, S. Ibarra, I. López, J. M. Santamaría, J. Cabo, David Vinuesa García, Jaime Lora-Tamayo, O. Murillo, S. Pedrero, S. Álvarez-Parrondo, R. Muedra-Font, C. Raya-Fernández, C. Rodríguez-Alonso, Antonio Vallecillo, M. A. Blanco-Martínez-de-Morentin, R. Cabo-Magadán, A. Combalía, S. García, J. Martínez-Pastor, E. Tornero, J. Merino-Pérez, J. Montejo, A. Alier, J. Horcajada, V. Plasencia, Lluís Puig, Álvaro Auñón, A. Blanco, J. García-Cañete, E. Sandoval, M. Fakkas-Fernández, C. Garces-Zarzalejo, C. Fariñas-Álvarez, M. Fariñas, L. Martínez-Martínez, Carlos A. Salas-Venero, J. Cobo, P. Ruiz-Carbajosa, M. Jordán, X. Crusi, C. Marinescu, F. Montaner, A. Ramírez, P. Corona, M. Lung, M. Muniain-Ezcurra, C. Peñas-Espinar, A. Suárez, Regino Rodríguez Álvarez, J. Cordero, M. López-Pliego, J. Palomino, A. Puente   +82 more
semanticscholar   +1 more source