Results 271 to 280 of about 5,638,528 (351)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Performance of established test methods for diagnosing chronic periprosthetic joint infections caused by low-virulence pathogens. [PDF]

Bone Joint Res
Luger M, Rabitsch L, McNally M, Rupp M, Böhler C, Staats K, Windhager R, Sigmund IK.   +7 more
europepmc   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Rapid and Accurate Diagnosis of Joint Infections: Potential Clinical Effect of the BioFire Joint Infection Panel. [PDF]

JB JS Open Access
Jeong HS, Choi SM, Kwon YJ, Jang MO, Kim MJ, Kim S, Lee A, Kim SE, Shin SU, Kim UJ, Kang SJ, Jung SI, Shin JH, Won EJ, Kim MN, Park KH.   +15 more
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Rapid Nanopore Sequencing to Identify Bacteria Causing Prosthetic Joint Infections. [PDF]

Antibiotics (Basel)
Wilkinson H, Wright K, McCarthy HS, Perry J, Hulme C, Steele N, Burston B, Townsend R, Cool P.   +8 more
europepmc   +1 more source

High Diagnostic Value of Synovial Biopsy in Periprosthetic Joint Infection of the Hip

, 2012
Bernd Fink, Alexander Gebhard, Martin Fuerst, Irina Berger, Peter Schäfer   +4 more
openalex   +2 more sources

National Guide on Nutrition Care and Support for People Living With HIV/AIDS\ud [PDF]

, 2003
Abdallah., Fatma, Charles, Tumaini, Elisaria,, Esther, Kimboka, Sabas, Kyungu, Lunna, Lorri, Wilbard, Lyatuu, Vumilia, Macha, Elizabeth, Magambo, Faith, Mboya, Pantaleo, Missano, Hilda, Ndossi, Godwin, Ngonyani, Monica, Nnally, Luitfrid, Ntoga, Bupe, Nyagawa, Daniel, Rwenyagira, Margeth, Sanga, Alfred, Semu, Hellen, Shirima, Restituta, Urio, Elisante   +20 more
core  

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Synovial Fluid MicroRNA Biomarkers Enable Accurate Diagnosis of Hip and Knee Periprosthetic Joint Infections. [PDF]

J Bone Joint Surg Am
Frank BJH, Krammer TL, Pfeiffer-Vogl J, Huong Nguyen TT, Diendorfer AB, Hackl M, Hofstaetter JG.   +6 more
europepmc   +1 more source