Results 21 to 30 of about 344,693 (260)

Fungal Periprosthetic Hip Joint Infections

Diagnostics, 2022
Introduction: Fungal hip prosthetic joint infections (PJIs) are rare but severe infections. Their incidence has increased in the last decades due to the aging population, as well as due to the increased number of immunosuppressed hosts.
Christos Koutserimpas, Symeon Naoum, Vasileios Giovanoulis, Konstantinos Raptis, Kalliopi Alpantaki, Konstantinos Dretakis, Georgia Vrioni, George Samonis   +7 more
doaj   +1 more source

Bone and joint infection [PDF]

Clinical Medicine, 2018
Bone and joint infections include septic arthritis, prosthetic joint infections, osteomyelitis, spinal infections (discitis, vertebral osteomyelitis and epidural abscess) and diabetic foot osteomyelitis. All of these may present through the acute medical take.
Julia, Colston, Bridget, Atkins
openaire   +2 more sources

Non-Candida Fungal Prosthetic Joint Infections

Diagnostics, 2021
Background: Fungal prosthetic joint infections (PJIs) are rare, especially those caused by non-Candida species. Treatment has not been fully elucidated, since a plethora of antifungal and surgical interventions have been proposed.
Christos Koutserimpas, Ifigeneia Chamakioti, Stylianos Zervakis, Konstantinos Raptis, Kalliopi Alpantaki, Diamantis P. Kofteridis, Georgia Vrioni, George Samonis   +7 more
doaj   +1 more source

Campylobacter Prosthetic Joint Infection [PDF]

Journal of Clinical Microbiology, 2014
ABSTRACTA 75-year-old man was diagnosed with probableCampylobacter jejuniprosthetic knee infection after a diarrheal illness. Joint aspirate and operative cultures were negative, but PCR of prosthesis sonicate fluid was positive, as was stool culture.
Shawn, Vasoo, Jeramy J, Schwab, Scott A, Cunningham, Trisha J, Robinson, Joseph R, Cass, Elie F, Berbari, Randall C, Walker, Douglas R, Osmon, Robin, Patel   +8 more
openaire   +2 more sources

Gonococcal Prosthetic Joint Infection [PDF]

Journal of Bone and Joint Infection, 2017
Abstract. Neisseria gonorrhoea is a common sexually transmitted infection worldwide. Disseminated gonococcal infection is an infrequent presentation and rarely can be associated with septic arthritis. Incidence of this infection is rising, both internationally and in older age groups. We present the first documented case of N.
I. Gassiep, I. Gassiep, B. Gilpin, B. Gilpin, J. Douglas, D. Siebert, D. Siebert   +6 more
openaire   +4 more sources

Development of a multicentre cohort study to understand the role of MRI and ultrasound in the diagnosis of acute haematogenous bone and joint infection in children (the PIC Bone study): a study protocol

Bone & Joint Open
Aims: Bone and joint infections (BJI) in children are rare but can be serious. Differentiating BJI from other conditions with similar symptoms is critical. Advanced imaging (ultrasound scans (USS) and MRI) is often required to confirm the diagnosis. The
Marie-Caroline Nogaro, Stuart Hartshorn, Mariea Brady, Amaka Offiah, Saul Faust, Gregory Firth, Jie Ma, Paula Dhiman, Joanna O'Mahoney, Loretta Davies, Catherine Spowart, Amy Moscrop, Bridget Young, Catrin Tudur-Smith, Gary Collins, Daniel C. Perry, Tim Theologis   +16 more
doaj   +1 more source

The role of BioFire Joint Infection Panel in diagnosing periprosthetic hip and knee joint infections in patients with unclear conventional microbiological results

Bone & Joint Research
Aims: This study aimed to evaluate the BioFire Joint Infection (JI) Panel in cases of hip and knee periprosthetic joint infection (PJI) where conventional microbiology is unclear, and to assess its role as a complementary intraoperative diagnostic tool.
Susana Gardete-Hartmann, Jennyfer A. Mitterer, Sujeesh Sebastian, Bernhard J. H. Frank, Sebastian Simon, Stephanie Huber, Marcellino Löw, Ian Sommer, Morjan Prinz, Milo Halabi, Jochen G. Hofstaetter   +10 more
doaj   +1 more source

Tolerance of Prolonged Oral Tedizolid for Prosthetic Joint Infections: Results of a Multicentre Prospective Study

Antibiotics, 2020
Objectives: Data on clinical and biological tolerance of tedizolid (TZD) prolonged therapy are lacking. Methods: We conducted a prospective multicentre study including patients with prosthetic joint infections (PJIs) who were treated for at least 6 weeks
Eric Senneville, Aurélien Dinh, Tristan Ferry, Eric Beltrand, Nicolas Blondiaux, Olivier Robineau   +5 more
doaj   +1 more source

Synchronous Periprosthetic Joint Infections: A Scoping Review of the Literature

Diagnostics, 2022
Prosthetic joint infections (PJIs) occurring in multiple joints at the same time (synchronous PJI) are an extremely rare complication, frequently associated with bacteremia, and are associated with high mortality rates.
Andrea Sambri, Emilia Caldari, Michele Fiore, Claudio Giannini, Matteo Filippini, Lorenzo Morante, Claudia Rondinella, Eleonora Zamparini, Sara Tedeschi, Pierluigi Viale, Massimiliano De Paolis   +10 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source