Results 291 to 300 of about 496,797 (347)

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Emerging Concepts for the Treatment of Biofilm-Associated Bone and Joint Infections with IV Fosfomycin: A Literature Review. [PDF]

Microorganisms
Tedeschi S, Giannitsioti E, Mayer C.
europepmc   +1 more source

A Human Immuno‐Lung Organoid Model to Study Macrophage‐Mediated Lung Cell Senescence Upon SARS‐CoV‐2 Infection

Advanced Science, EarlyView.
Immuno‐lung organoids are developed and used spatial transcriptomics to uncover how proinflammatory macrophages drive lung cell senescence via the THBS1–(ITGA3+ITGB1) axis in COVID‐19. To ensure broad accessibility, LungSpatialDB is created, an AI‐powered data portal, enabling intuitive exploration of spatial data and biological insights through ...
Yuling Han, Dongliang Leng, Tuo Zhang, Jian Ge, Yinshan Fang, Tiankun Lu, Xue Dong, Manoj S Nair, Neranjan de Silva, Zhaowei Han, Tiancheng Jiao, Yuanhao Huang, Meiqi Zhao, Anjali Saqi, Hanina Hibshoosh, Zihe Meng, Jenny Z Xiang, Chendong Pan, Yanjie Sun, David D. Ho, Todd Evans, Jie Liu, Liuliu Yang, Jianwen Que, Shuibing Chen   +24 more
wiley   +1 more source

Comparison of Microbiological Profiles of Primary Hip and Knee Peri-Prosthetic Joint Infections Treated at Specialist Centers Around the World. [PDF]

Microorganisms
Dedeogullari ES, Slullitel P, Horton I, Atilla B, Salih S, Monk P, Tokgozoglu AM, Goplen M, Tsang B, Buljubasich M, Abdelbary H, Garceau S, Grammatopoulos G.   +12 more
europepmc   +1 more source

Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction

Advanced Science, EarlyView.
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu, Huitong Ruan, Xiaolin Zhang, Weihan Zheng, Muhetaierjiang Mutailifu, Ling Wang, Liu Yu, Ruijun Peng, Rui Zhao, Zihan Wang, Jie Xu, Shaochuan Li, Yaobin Wu, Wenguo Cui, Mujun Lu   +14 more
wiley   +1 more source

Preparation and pharmacokinetic evaluation of Staphylococcus phage COP-80B for treatment of periprosthetic joint infections in a mouse model. [PDF]

Virus Res
Štilec V, Marušić M, Janež N, Bezeljak U, Rebula L, Leskovec M, Trebše R, Horvat S, Peterka M.   +8 more
europepmc   +1 more source

Synovial fluid viscosity with synovial fluid cell count, valuable diagnostic marker of prosthetic joint infections. [PDF]

Sci Rep
Roškar S, Mihalič R, Mihelič A, Trebše R.   +3 more
europepmc   +1 more source

Comparison Between Septic Arthritis Alone and Coexisting with Other Bone and Joint Infections in Pediatric Patients: A Retrospective Review. [PDF]

JB JS Open Access
Favre NM, De Marco G, Vazquez O, Chargui A, Tabard-Fougère A, Cochard B, Steiger C, Dayer R, Ceroni D.   +8 more
europepmc   +1 more source

Prosthetic Joint Infections due to Candida Species: A Multicenter International Study. [PDF]

Clin Infect Dis
Dinh A, McNally M, D'Anglejan E, Mamona Kilu C, Lourtet J, Ho R, Scarborough M, Dudareva M, Jesuthasan G, Ronde Oustau C, Klein S, Escolà-Vergé L, Rodriguez Pardo D, Delobel P, Lora-Tamayo J, Mancheño-Losa M, Sorlí Redó ML, Barbero Allende JM, Arvieux C, Vaznaisiène D, Bauer T, Roux AL, Noussair L, Corvec S, Fernández-Sampedro M, Rossi N, Lemaignen A, Costa Salles MJ, Cunha Ribeiro T, Mazet J, Sasso M, Lavigne JP, Sotto A, Canouï E, Senneville É, Thill P, Lortholary O, Lanternier F, Morata L, Soriano A, Giordano G, Fourcade C, Frank BJH, Hofstaetter JG, Duran C, Bonnet E, European Society of Clinical Microbiology and Infectious Diseases Study Group on Implant Associated Infections (ESGIAI).   +46 more
europepmc   +1 more source

A Comparison of Causative Pathogens in Bone and Prosthetic Joint Infections: Implications for Antimicrobial Therapy. [PDF]

Antibiotics (Basel)
Unsworth A, Young B, Scarborough M, McNally M.   +3 more
europepmc   +1 more source