Results 31 to 40 of about 37,962 (266)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Joint Inversion of Compact Operators

Journal of Inverse and Ill-posed Problems, 2018
Abstract Joint inversion of multiple data types was studied as early as 1975 in [K. Vozoff and D. L. Jupp, Joint inversion of geophysical data, Geophys. J. Internat. 42 1975, 3, 977–991], where the authors used the singular value decomposition to determine the degree of ill-conditioning of joint inverse problems. The authors demonstrated
Jodi L. Mead, James F. Ford
openaire   +4 more sources

Status and prospects of joint inversion of geophysical electromagnetic data

地球与行星物理论评
Geophysical electromagnetic data inversion is a typical underdetermined problem. Due to the limitations of observational data, individual geophysical methods often suffer from significant non-uniqueness and uncertainty, making it challenging to provide ...
Laonao Wei, Yongji Li, Changchun Yin, Yang Su, Yunhe Liu   +4 more
doaj   +1 more source

Efficient Probabilistic Joint Inversion of Direct Current Resistivity and Small-Loop Electromagnetic Data

Algorithms, 2020
Often, multiple geophysical measurements are sensitive to the same subsurface parameters. In this case, joint inversions are mostly preferred over two (or more) separate inversions of the geophysical data sets due to the expected reduction of the non ...
Christin Bobe, Daan Hanssens, Thomas Hermans, Ellen Van De Vijver   +3 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Structural joint modeling of magnetotelluric data and Rayleigh wave dispersion curves using Pareto-based particle swarm optimization: an example to delineate the crustal structure of the southeastern part of the Biga Peninsula in western Anatolia [PDF]

Nonlinear Processes in Geophysics
It is widely acknowledged that the joint inversion of magnetotelluric and seismological datasets enhances the quality of the crustal structure solution, even when the physical correlation between electrical resistivity and seismic velocity is weak or ...
E. Büyük, E. Büyük, E. Zor, M. C. Tapırdamaz   +3 more
doaj   +1 more source

The waveform inversion of mainshock and aftershock data of the 2006 M6.3 Yogyakarta earthquake

Geoscience Letters, 2021
This study comprehensively investigates the source mechanisms associated with the mainshock and aftershocks of the Mw = 6.3 Yogyakarta earthquake which occurred on May 27, 2006.
Hijrah Saputra, Wahyudi Wahyudi, Iman Suardi, Ade Anggraini, Wiwit Suryanto   +4 more
doaj   +1 more source

Observer‐Based Adaptive Event‐Triggered Tracking Control for Fuzzy TS Systems With Premise Mismatch

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper presents an adaptive logistic event‐triggered observer‐based tracking controller for Takagi‐Sugeno fuzzy systems under constrained inputs and network delays. Leveraging a hybrid LMI and Secretary Bird Optimization approach, this strategy significantly minimizes communication overhead and computational burden while ensuring optimal reference ...
Oussama Djadane, Salama Makni, Mourad Kchaou, Ahmed El Hajjaji   +3 more
wiley   +1 more source