Results 221 to 230 of about 2,895,344 (297)

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

open access: yesAdvanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao   +8 more
wiley   +1 more source

Molecular MRI Reveals Macrophage‐Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer

open access: yesAdvanced Science, EarlyView.
Incomplete microwave ablation (iMWA) induced a spatially organized, macrophage‐rich immunosuppressive tumor microenvironment (TME) in orthotopic VX2 liver tumors. Molecular MRI enhanced with europium‐doped very small superparamagnetic iron oxide nanoparticles (Eu‐VSOP) noninvasively visualized this remodeling, showing preferential nanoparticle ...
Yubei He   +22 more
wiley   +1 more source

A Multi‐Structural Radiomic Digital Phenotyping Framework for Deciphering Preclinical Evolution of Degenerative Meniscal Tears

open access: yesAdvanced Science, EarlyView.
Subclinical matrix disruption precedes degenerative meniscal tears across the knee joint. A spatial compartmental radiomics model utilizing 3D‐DESS MRI captures early osteochondral destabilization, accurately predicting incident tears up to four years pre‐collapse. Feature attributions uncover coordinated chondral and osseous alterations, advancing non‐
Shengfa Li   +13 more
wiley   +1 more source

Management of sacroiliac joint pain: current concepts. [PDF]

open access: yesEur J Orthop Surg Traumatol
Migliorini F   +5 more
europepmc   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu   +5 more
wiley   +1 more source

U.S. Agriculture, Biofuel Markets, and Trade: Challenges and Opportunities

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT Using an enhanced Computable General Equilibrium (CGE) model (GTAP‐BIO), this study assesses how the expansion in demand for Electric Vehicles (EVs) and the reduction in exports of agricultural products induced by trade disputes negatively affect US agriculture.
Rayan Wolf, Farzad Taheripour
wiley   +1 more source

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