Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
From Agent-Based Markov Dynamics to Hierarchical Closures on Networks: Emergent Complexity and Epidemic Applications. [PDF]
Entropy (Basel)Klimenko AY, Rozycki A, Lu Y.
europepmc +1 more source
The method of joint probability distribution functions applied to SIR-MIR and to SIRAS-MIRAS cases.
Acta Crystallographica Section A Foundations of Crystallography, 2002 C. Giacovazzo, D. Siliqi
semanticscholar +1 more source
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
Stable de novo protein design via joint conformational landscape and sequence optimization. [PDF]
Nat CommunCho Y +4 more
europepmc +1 more source
Advanced Science, EarlyView.A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son +2 more
wiley +1 more source
On Bell's Joint Probability Distribution and Proposed Experiments of Quantum Measurement [PDF]
, 2009 Hai-Long Zhao
openalex
Joint Probability Distribution of Extreme Wind Speed and Air Density Based on the Copula Function to Evaluate Basic Wind Pressure [PDF]
Lianpeng Zhang +6 more
openalex +1 more source
On the role of joint probability distributions of incompatible observables in Bell and Kochen–Specker Theorems [PDF]
, 2019 Ángel Rivas
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