Results 41 to 50 of about 2,950,505 (264)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Blockchain and IoT-based architecture design for intellectual property protection

International Journal of Crowd Science, 2020
PurposeThe blockchain technology provides a way to record transactions that is designed to be highly secure, transparent, trustable, traceable, auditable and tamper-proof. And, the internet of things (IoT) technology provides the ability to transfer data
Jun Lin, Wen Long, Anting Zhang, Yueting Chai   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Beyond Joint Property? Examining Fiqh Munakahat, State Law, and Customary Practice in Aceh, Indonesia

Usraty
This study aims to reconstruct the concept of joint marital property in Aceh by examining how statutory law, Islamic jurisprudence, and customary law interact in the resolution of marital property disputes.
Musfira Musfira, Putri Rahmah Nur Hakim, Khairani Mukdin, Irwan Abdullah, Syahrizal Abbas, Salmy Edawati Yaacob   +5 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

TINJAUAN MAQĀSID SYARĪAH TERHADAP PERKARA HARTA BERSAMA DAN KONTRIBUSINYA DALAM PEMBARUAN HUKUM KELUARGA ISLAM DI INDONESIA (Studi Kasus di Wilayah Hukum Pengadilan Tinggi Agama Bengkulu)

Ijtimaiyya, 2020
The problem of joint property disputes after divorce in the jurisdiction of the Bengkulu Religious high courts, in the period 2010 to 2015 all decisions are always made up of half of the property of the ex-wife and the other half of the property of the ...
Zuhri Imansyah, Jayusman Jayusman, Erina Pane, Efrinaldi Efrinaldi, Iim Fahimah   +4 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

QUALIFICATION AND LEGAL CONSEQUENCES OF CIVIL TRANSACTIONS CONDUCTED BETWEEN SPOUSES REGARDING COMMON JOINT PROPERTY [PDF]

Legal Bulletin
The relevance of the research is related to the ongoing discussion about the legal consequences of civil law transactions concluded by spouses regarding common joint property.
USACHEVA ELENA
doaj   +1 more source