Results 201 to 210 of about 7,506,901 (288)

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

The return to work after arthroplasty (REWARD) cohort: a nationwide longitudinal study of sick leave and disability pension among individuals receiving hip and knee arthroplasty in Sweden. [PDF]

BMJ Open
Gustafsson K, Liv P, Rolfson O, Kuijer PPFM, Mukka S, Wahlström J.   +5 more
europepmc   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Suture-Button Stabilisation for Thumb Carpometacarpal Joint Instability and Dislocation: A Retrospective Case Series. [PDF]

Hand (N Y)
Gao D, Sungaran J, McCarron L, Sivakumar B, Graham DJ.   +4 more
europepmc   +1 more source

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

Advanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao, Han Wu, Shaorong Li, Weijian Wang, Yijian Guo, Shuai Cheng, Jiayi Sun, Jilong An, Wei Zhang   +8 more
wiley   +1 more source

Return to Work After Hematopoietic Stem Cell Transplantation: A Longitudinal Analysis of Fatigue and Organ-Specific Chronic Graft-versus-Host Disease. [PDF]

Blood Cell Ther
Chiang MK, Hsiao YM, M Ali A, Tan TD, Chiou LW.   +4 more
europepmc   +1 more source

Pre‐Refinement Prediction of Dopant Site Occupancy in M‐Type Hexaferrites via Hierarchical and Uncertainty‐Aware Machine‐Learning

Advanced Science, EarlyView.
Refined data are extracted from CIF files to construct a hierarchical machine‐learning framework integrating sublattice classification, Fe‐site occupancy prediction, and reliability assessment. External validation yields 96% accuracy for sublattice classification and a macro mean absolute error of 0.0584 for Fe‐site prediction.
Dan Liu, Jianyu Ren, Ruoshui Liu, Yinong Yin, Jianfeng Xi, Xin Ming, Jiazheng Hao, Tongyun Zhao, Fengxia Hu, Baogen Shen   +9 more
wiley   +1 more source

Is Joint Denervation a Durable Treatment for Thumb Carpometacarpal Osteoarthritis? A Multicenter Long-Term Outcome Study. [PDF]

Plast Reconstr Surg
Nieuwdorp NJ, Blaaker C, Kwee E, Walbeehm ET, Selles RW, Eberlin KR, Zuidam JM, Hundepool CA, Hand-Wrist Study Group.   +8 more
europepmc   +1 more source

Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor‐Expressing Neurons in the Medial Prefrontal Cortex

Advanced Science, EarlyView.
This study shows that propofol modulates fear‐memory reconsolidation in mice. It works by suppressing D2 receptor‐expressing neurons within the medial prefrontal cortex and their connections to the basolateral amygdala. D2‐receptor agonists reproduce this fear‐reducing effect, offering potential non‐anesthetic therapeutic strategies for trauma‐related ...
Jie Li, Yi‐Ge Guo, Xing Xu, Gui‐Lin Meng, Han Li, Liu‐Wei Chu, Xin‐Yuan Chen, Xiao‐Yun Guo, Tao Xu, Ti‐Fei Yuan, Ji Hu, Xiao‐Na Zhu   +11 more
wiley   +1 more source