Results 41 to 50 of about 4,227 (265)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Winter Wheat Phenology Variation and Its Response to Climate Change in Shandong Province, China

Remote Sensing, 2022
Crop phenology is considered to be an important indicator reflecting the biophysical and physiological processes of crops facing climate change. Therefore, quantifying crop phenology change and its relationship with climate variables is of great ...
Yijing Zhao, Xiaoli Wang, Yu Guo, Xiyong Hou, Lijie Dong   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Efecto del rectificado y desgaste de cuchillos en la calidad superficial de molduras de pino radiata Jointing knives and tool wear effect in the surface quality of radiata pine moldings

Maderas: Ciencia y Tecnología, 2012
Se estudia el efecto que ejerce el talón de rectificado de cuchillos en acero rápido sobre la calidad superficial de molduras sólidas de pino radiata.
Alfredo Aguilera, Christopher Fernández
doaj  

Winter wheat yield responses to growing degree days: Long-term trends and adaptability in major producing areas of China

Ecological Indicators
Global warming significantly impacts wheat production, altering growing degree days (GDD), a key indicator of heat accumulation essential for crop growth.
Ziyang Liu, Davide Cammarano, Xiaojun Liu, Yongchao Tian, Yan Zhu, Weixing Cao, Qiang Cao   +6 more
doaj   +1 more source

Photosynthetic Carbon Fixation and Sucrose Metabolism Supplemented by Weighted Gene Co-expression Network Analysis in Response to Water Stress in Rice With Overlapping Growth Stages

Frontiers in Plant Science, 2022
Drought stress at jointing and booting phases of plant development directly affects plant growth and productivity in rice. Limited by natural factors, the jointing and booting stages in rice varieties are known to overlap in high-latitude areas that are ...
Xinpeng Wang, Hualong Liu, Di Zhang, Detang Zou, Jingguo Wang, Hongliang Zheng, Yan Jia, Zhaojun Qu, Bin Sun, Hongwei Zhao   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mathematical model of splicing of steel cable [PDF]

Научно-технический вестник Брянского государственного университета, 2019
he article presents materials on the study of mathematical modeling of jointing (splicing) of a steel rope used to transfer the traction force by friction forces.
Korotkiy A.A., Marchenko E.V., Panfilov A.V.   +2 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Efecto del rectificado y desgaste de cuchillos en la calidad superficial de molduras de Pino radiata

Maderas: Ciencia y Tecnología, 2014
Se estudia el efecto que ejerce el talón de rectificado de cuchillos en acero rápido sobre la calidad superficial de molduras sólidas de pino radiata.
Alfredo Aguilera, Christopher Fernández
doaj