Results 121 to 130 of about 500,766 (315)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

NEW TRENDS OF ACHIEVEMENT OF ECOLOGICAL LIGHTWEIGHT WOODEN MATERIAL [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2014
The dominant trend both abroad and in our country is phasing out heavy concrete and replace them with alternative building materials that meet tenants health and the environment.
Adelaida Cristina HONŢUŞ
doaj  

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Reduced joint models for damping design of multi-jointed structures [PDF]

, 2014
− Design of damping in multi-jointed structures is studied here. − Dissipation sources are viscoelastic behavior and contact/friction at joints interfaces. − Reduction on meta-models of nonlinear joints models is investigated.
BALMES, Etienne, GUSKOV, Mikhail, HAMMAMI, Chaima   +2 more
core  

Unilateral Single Joint Arthritis Changes Joint Power in Unaffected Joints

Journal of Orthopaedic Research
ABSTRACTPain and disability associated with arthritis of the hip, knee, or ankle is well‐documented. However, data on joint power and how arthritis in one joint affects power in that joint and in unaffected joints are limited. This study asks if arthritis in any one joint leads to (1) loss of power in that affected joint compared to the contralateral ...
James Campbell, Daniel Schmitt, Laura P. Sands, Robin M. Queen   +3 more
openaire   +3 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Evaluation of the Factors Affecting Opening-Closing Performance of Wooden Cabinet Doors

BioResources, 2023
This study determined the deflection performance of wooden cabinet doors during opening and closing by using different material types, opening-closing angle, and load force. The independent variables consisted of material type, opening-closing angle, and
Emine Seda Erdinler, Sedanur Seker, Ender Hazır, Kucuk Huseyin Koc   +3 more
doaj  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Experimental and numerical investigation on composite beam–column joint connection behavior using different types of connection schemes

Open Engineering
Over the past few decades, composite joints have been regarded as one of the most promising approaches. After reviewing the research articles dealing with composite beam-column joints, it can be withdrawn that few researchers studied and developed ...
Askar Lawend Kamal, Al-Darzi Suhaib Yahya Kasim, Al-Sulayfani Bayar Jafar Mohamed   +2 more
doaj   +1 more source