MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary α-tryptasemia [PDF]
IntroductionHereditary α-tryptasemia (HαT), defined by increased TPSAB1 copy number and elevated basal serum tryptase, is associated with mast cell (MC)–mediated symptoms. However, its role in gastrointestinal disease remains unclear.
Michelle Galeas-Pena +19 more
doaj +2 more sources
Lessons from the PROTECT-CH COVID-19 platform trial in care homes
Background Coronavirus disease-2019 was associated with significant mortality and morbidity in care homes in 2020–1. Repurposed antiviral drugs might reduce morbidity and mortality through reducing viral transmission, infection, replication and ...
Philip M Bath +25 more
doaj +2 more sources
Anterior Cruciate Ligament Reconstruction With Bone–Patellar Tendon–Bone Autograft With Concomitant Meniscal Allograft Transplantation [PDF]
Background: Primary arthroscopic-assisted anterior cruciate ligament (ACL) reconstruction using a bone–patellar tendon–bone (BTB) graft offers excellent long-term results for patients with ACL tears.
Jonathan D. Groothoff MA +6 more
doaj +2 more sources
Cross-Neutralization of Distant Coronaviruses Strongly Correlates with Spike S2-Specific Antibodies from Immunocompetent and Immunocompromised Vaccinated SARS-CoV-2-Infected Patients [PDF]
Background/Objectives: Despite the lifting of the COVID-19 public health emergency, SARS-CoV-2 infections continue to be recorded worldwide. The continued prevalence of infection has been attributed to the ability of the virus to evade host immune ...
Sara V. Patel +31 more
doaj +2 more sources
Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity [PDF]
Summary: Many individuals with type 2 diabetes (T2D) cannot take current therapies due to their adverse effects. Thus, new glucose-lowering agents targeting unique mechanisms are needed.
Seyed Amirhossein Tabatabaei Dakhili +23 more
doaj +2 more sources
Jonathan Glover, Questions de vie ou de mort
exaly +3 more sources
Inconsistencies in mapping current distribution in transcranial direct current stimulation
IntroductiontDCS is a non-invasive neuromodulation technique that has been widely studied both as a therapy for neuropsychiatric diseases and for cognitive enhancement.
Anita S. Jwa +2 more
doaj +1 more source
Objectives The National Early Warning Score 2 (NEWS2) is validated for predicting acute deterioration, however, the binary grading of inspired oxygen fraction (FiO2) may limit performance.
Jonathan Clarke +4 more
doaj +1 more source
Recent studies have demonstrated that fast fMRI can track neural activity well above the temporal limit predicted by the canonical hemodynamic response model.
Jingyuan E. Chen +5 more
doaj +1 more source
Creasing in microscale, soft static friction
Utilizing colloidal probe, lateral force microscopy and simultaneous confocal microscopy, combined with finite element analysis, we investigate how a microparticle starts moving laterally on a soft, adhesive surface.
Justin D. Glover +3 more
doaj +1 more source

