Results 171 to 180 of about 80,821 (253)

Characterizing early behavioral and social–emotional problems in young children with SCN1A+ Dravet syndrome: Findings from the ENVISION prospective natural history study

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is the prototypic developmental and epileptic encephalopathy, characterized by drug‐resistant seizures, developmental slowing, and many other morbidities. Detailed characterization of behavioral phenotypes and social–emotional skill development are limited.
Ingrid E. Scheffer, M. Scott Perry, Joseph Sullivan, Susana Boronat, James Wheless, Andreas Brunklaus, Linda Laux, Anup D. Patel, Colin Roberts, Dennis Dlugos, Deborah Holder, Kelly Knupp, Matt Lallas, Steven Phillips, Eric Segal, Dennis Lal, Elaine Wirrell, Sameer M. Zuberi, Rebecca Shaffer, Mary Wojnaroski, Madison M. Berl, Sarah Christensen, Emma S. James, Maria Candida Vila, Norman Huang, Jacqueline S. Gofshteyn, Salvador Rico   +26 more
wiley   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors. [PDF]

Cancer Res
ElHarouni D, Hernansaiz-Ballesteros R, Peterziel H, Balasubramanian GP, Previti C, Schramm K, Blattner-Johnson M, Kabbe R, Jones BC, Oppermann S, Jones DTW, Pfister SM, Witt O, Saez-Rodriguez J, Oehme I, Jäger N, Schlesner M.   +16 more
europepmc   +1 more source

A Deep Learning Framework for Forecasting Medium‐Term Covariance in Multiasset Portfolios

Journal of Forecasting, EarlyView.
ABSTRACT Forecasting the covariance matrix of asset returns is central to portfolio construction, risk management, and asset pricing. However, most existing models struggle at medium‐term horizons, several weeks to months, where shifting market regimes and slower dynamics prevail.
Pedro Reis, Ana Paula Serra, João Gama
wiley   +1 more source

Theory-independent monitoring of the decoherence of a superconducting qubit with generalized contextuality. [PDF]

Nat Commun
Aloy A, Fadel M, Galley TD, Jones CL, Müller MP.   +4 more
europepmc   +1 more source

Molecular Palaeontology Prospects From Exceptionally Preserved Eocene Brackish‐Water Bivalve Batissa sitakaraensis (Venerida: Corbiculidae) From Hokkaido, Japan

Geological Journal, EarlyView.
This study reports the exceptional preservation of the Eocene freshwater bivalve Batissa sitakaraensis from Hokkaido, Japan. Multimodal analyses reveal that both the aragonitic shell mineralogy and the delicate organic periostracum retain their original structural and chemical characteristics after millions of years.
Taro Yoshimura, Kazuki Hirota, Hiroyuki Kagi, Takashi Matsubara, Takenori Sasaki   +4 more
wiley   +1 more source

Analysis of polarization aberrations of the off-axis pupil freeform optical system. [PDF]

iScience
Gong C, Zhang Y, Liu W, Wang J, Fu Q, Shi H.   +5 more
europepmc   +1 more source

Employee Delight: Conceptualization, Antecedents, and Consequences

Human Resource Development Quarterly, EarlyView.
ABSTRACT This article examines the concept of employee delight as a distinct construct within organizational behavior. Based on a systematic literature review, we analyze 10 empirical studies that explicitly address this phenomenon. We propose a multidimensional conceptualization of employee delight as an affective state of highly positive valence and ...
Dalilis Escobar‐Rivera, Alba Manresa, Eva Rimbau‐Gilabert   +2 more
wiley   +1 more source

A high-throughput biocatalytic platform for screening isomeric kainoid natural products. [PDF]

Cell Rep Phys Sci
Shepherd RA, Ramachandra M, Hopiavuori AR, Jones MC, Fihn CA, Tabag AJ, Manjunath A, Gad LY, Whipple CR, McKinnie SMK, Sanchez LM.   +10 more
europepmc   +1 more source

Spiritual Cannibalism in HRD: How Workplace Spirituality Devours Sacred Traditions

Human Resource Development Quarterly, EarlyView.
ABSTRACT This paper interrogates how the discourse of workplace spirituality in human resource development (HRD) operates as a tool of colonization. Through a systematic review of 48 articles published between 1997 and March 2025, the study uncovers recurring patterns of spiritual appropriation in which non‐Western traditions are detached from their ...
Shoaib Ul‐Haq
wiley   +1 more source