Results 1 to 10 of about 201 (78)

Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein–energy malnutrition in predementia aged people: study protocol for Choko-Age [PDF]

open access: yesBMJ Open, 2023
Objective Protein–energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia.
Jose Viña   +24 more
doaj   +2 more sources

Long-Term Impact of the COVID-19 Pandemic on In-Hospital Antibiotic Consumption and Antibiotic Resistance: A Time Series Analysis (2015–2021) [PDF]

open access: yesAntibiotics, 2022
The coronavirus disease 2019 (COVID-19)-pandemic-related overload of health systems has compromised the application of antimicrobial stewardship (AS) models and infection prevention and control (IPC) programs.
Marianna Meschiari   +16 more
doaj   +2 more sources

Safety and Non-Inferiority Evaluation of Two Immunization Schedules with an Inactivated SARS-CoV-2 Vaccine in Adults: A Randomized Clinical Trial [PDF]

open access: yesVaccines, 2022
Several vaccines have been developed to control the COVID-19 pandemic. CoronaVac®, an inactivated SARS-CoV-2 vaccine, has demonstrated safety and immunogenicity, preventing severe COVID-19 cases.
Katia Abarca   +30 more
doaj   +2 more sources

Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adultsResearch in context [PDF]

open access: yesEBioMedicine, 2023
Summary: Background: The Omicron variant has challenged the control of the COVID-19 pandemic due to its immuno-evasive properties. The administration of a booster dose of a SARS-CoV-2 vaccine showed positive effects in the immunogenicity against SARS ...
Constanza Méndez   +154 more
doaj   +2 more sources

Under-Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle-Based Approach for Microscale Cell Culture. [PDF]

open access: yesAdv Sci (Weinh), 2022
Autonomously regulated oxygen microenvironments (AROM), a Goldilocks principle‐based method that recapitulates the oxygen homeostasis and kinetics seen in vivo, is introduced in under‐oil open microfluidic systems (UOMS). Compared to the traditional, operator‐centered oxygen control, AROM allows cells to self‐regulate (i.e., autonomously regulate) and ...
Li C   +14 more
europepmc   +2 more sources

Engineering resource allocation in artificially minimized cells: Is genome reduction the best strategy? [PDF]

open access: yesMicrob Biotechnol, 2023
We quantitatively assessed the difference of reducing genome to the correspondence of reducing proteome. We compare the approaches in terms of energy consumption, defined in ATP equivalents. We aim to show what is the best strategy for improving resource allocation in minimized cells.
Marquez-Zavala E, Utrilla J.
europepmc   +2 more sources

A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit [PDF]

open access: yesAntimicrobial Resistance and Infection Control, 2021
Background Carbapenem-resistant Acinetobacter baumannii (CRAB) infection outbreaks are difficult to control and sometimes require cohorting of CRAB-positive patients or temporary ward closure for environmental cleaning. We aimed at controlling the deadly
Marianna Meschiari   +18 more
doaj   +2 more sources

Exercise promotes cognition and hippocampal mitochondrial complex II expression in female rats. [PDF]

open access: yesExp Physiol
ABSTRACT Evidence supports that exercise defends against age‐associated declines in brain health and protects against neurodegenerative disease. To help understand the molecular basis for the neuroprotection, we examined the impact of training on mitochondrial protein expression within the exercise–brain axis.
White ZJ   +3 more
europepmc   +2 more sources

Surgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 studyResearch in context [PDF]

open access: yesThe Lancet Regional Health. Western Pacific
Summary: Background: There is ongoing controversy as to whether surgical intervention to haematoma evacuation benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate
Xin Hu   +678 more
doaj   +2 more sources

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study [PDF]

open access: yesThe Lancet Global Health, 2022
Summary: Background: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown.
Stephen R Knight   +2861 more
doaj   +2 more sources

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