Results 151 to 160 of about 103,512 (241)

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

open access: yesAngewandte Chemie International Edition, Accepted Article.
High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS’s ability to directly assess drug‐protein interactions at endogenous levels, particularly in subcellular contexts.
Shuqi Li   +10 more
wiley   +1 more source

Highly Crystalline and Oriented Thin Films of Fully Conjugated 3D‐Covalent Organic Frameworks

open access: yesAngewandte Chemie International Edition, Accepted Article.
Fully conjugated three‐dimensional covalent organic frameworks (COFs) are a newly emerged class of materials that expands reticular chemistry to extended electron delocalization for optoelectronic applications. To overcome the limitations of sp3‐connected 3D frameworks, the pseudo‐tetrahedral motif cyclooctatetrathiophene (COTh) has gained attention ...
Ignacio Munoz-Alonso   +9 more
wiley   +1 more source

Single‐Molecule Protein Profiling Using Nanopores and Dimeric Aptamer‐Modified DNA Carriers

open access: yesAngewandte Chemie International Edition, Accepted Article.
Single‐molecule protein profiling offers unparalleled sensitivity for detecting rare biomarkers, with significant potential for early disease diagnosis and monitoring. Nanopore sensors enable the detection of proteins in solution and are well‐suited for clinical applications due to their high sensitivity and throughput.
Aleksandar Ivanov   +4 more
wiley   +1 more source

Angularly Resolved Tip‐Enhanced Raman Spectroscopy

open access: yesAngewandte Chemie International Edition, Accepted Article.
Despite intensive research in tip‐enhanced Raman spectroscopy (TERS), the angular distribution of Raman scattering in the TERS gap remains experimentally unreported leaving its relevance to the TERS signal formation to be seldomly discussed. Here, we investigate the angular distribution of the tip‐enhanced Raman signal in the Fourier plane using a ...
Felix Schneider   +10 more
wiley   +1 more source

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