Results 41 to 50 of about 712,583 (288)

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Между Прустом и Джойсом: Вехи на пути к Aбсолюту [Between Proust and Joyce: Markers on the way to the Absolute]

Slavica Revalensia, 2016
In this article Olga Demidova provides a detailed analysis of the critical reception of Marcel Proust and James Joyce in Russian émigré literature of the Interwar years.
Olga Demidova
doaj   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Impact of late ventricular fibrillation on postdischarge 1-year mortality of patients presenting with acute myocardial infarction: a nationwide retrospective study

BMJ Open
Objective To assess the impact of in-hospital late ventricular fibrillation (VF) (>48 hours) on the 1-year mortality risk among patients presenting with acute myocardial infarction (AMI) who survived the index hospitalisation.Design Retrospective ...
Gal Tsaban, Moti Haim, Yael Israeli Hadar, Yigal Abramowitz, Blake Filderman, Rodrigue Garcia, Hilmi Alnsasra   +6 more
doaj   +1 more source

A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer

OncoImmunology, 2018
Mutated cancer antigens, or neoantigens, represent compelling immunological targets and appear to underlie the success of several forms of immunotherapy.
Spencer D. Martin, Darin A. Wick, Julie S. Nielsen, Nicole Little, Robert A. Holt, Brad H. Nelson   +5 more
doaj   +1 more source

A Lagrangian Neighbourhood Theorem for shifted symplectic derived schemes [PDF]

, 2015
Pantev, Toen, Vaqui\'e and Vezzosi arXiv:1111.3209 defined $k$-shifted symplectic derived schemes and stacks ${\bf X}$ for $k\in\mathbb Z$, and Lagrangians ${\bf f}:{\bf L}\to{\bf X}$ in them.
Joyce, Dominic, Safronov, Pavel
core   +3 more sources

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Retratos do missivista quando jovem: figurações do artista moderno na correspondência amorosa de James Joyce

Ilha do Desterro, 2021
Abordamos, neste trabalho, a epistolografia amorosa do escritor irlandês James Joyce endereçada a sua mulher Nora Barnacle a partir das personas que o missivista desenvolve em suas cartas.
Rangel Gomes de Andrade, Adalberto Luis Vicente   +1 more
doaj   +1 more source

The Impact of Job Strain on Occupational Access to Firearms and Firearm‐Related Suicide Among US Workers

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Introduction Firearm‐related suicide rates are notably high among workers such as police officers and farmers. One risk factor is occupational access to firearms, but other occupational characteristics, such as job strain, are less understood.
Victor A. Soupene, Jonathan Davis, Joseph E. Cavanaugh, Jonathan M. Platt, Paul A. Romitti, Carri Casteel   +5 more
wiley   +1 more source

Case series: Point-of-Care Ultrasound Conducted by Medical Students During their First Clinical Rotation Changes Patients’ Primary Diagnosis and Management

International Journal of Medical Students, 2021
Background: As point-of-care ultrasound (POCUS) becomes a standard of care procedure, medical schools around the world have started to seek the integration of POCUS courses into their curricula.
Re'em Sadeh, Tomer Gat, Omer Kaplan, Tzvika Porges, Lior Zeller, Leonid Barski, Lior Fuchs   +6 more
doaj   +1 more source