Results 101 to 110 of about 1,736,784 (299)
Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly
Advanced Science, EarlyView.Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao +5 more
wiley +1 more source
El Cura de Ars en el magisterio pontificio, de San Pío X a Benedicto XVI. [PDF]
, 2010 El trabajo pretende mostrar como los papas del siglo XX se han servido de la figura del Cura de Ars para reafirmar la identidad fundamental del sacerdote católico.
Blot, D. (Dominique)
core
Advanced Science, EarlyView.An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia +6 more
wiley +1 more source
Journal of Experimental and Theoretical AnalysesStress is a natural response of the organism to challenging situations, but its accurate detection is challenging due to its subjective nature. This study proposes a model based on depth-separable convolutional neural networks (DSCNN) to analyze heart ...
Rodrigo Mateo-Reyes +2 more
doaj +1 more source
Valero Juan, Eva. Ercilla y La Araucana en dos tiempos. Del Siglo de Oro a la posteridad. Sevilla: Renacimiento, 2016. 194 pgs. ISBN: 9788416981007 [PDF]
, 2017 Ressenya del llibre: Valero Juan, Eva. Ercilla y La Araucana en dos tiempos. Del Siglo de Oro a la posteridad. Sevilla: Renacimiento, 2016.Book review: Valero Juan, Eva. Ercilla y La Araucana en dos tiempos. Del Siglo de Oro a la posteridad.
Cortijo Ocaña, Antonio
core
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Medical SciencesBackground: Chronic pain is a prevalent and disabling condition, affecting 20–30% of the global population, which requires multidisciplinary approaches integrating non-pharmacological therapies and promoting patient engagement in self-management ...
María Victoria Ruiz-Romero +9 more
doaj +1 more source
Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity
Advanced Science, EarlyView.In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin +19 more
wiley +1 more source